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Related Experiment Video

Updated: Apr 19, 2026

Isolation of Primary Mouse Trophoblast Cells and Trophoblast Invasion Assay
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[Gestational trophoblastic disease].

Fabienne Allias1, Pierre-Adrien Bolze2, Lucie Gaillot-Durand3

  • 1Service de pathologie Nord, hôpital de la Croix Rousse, hospices civils de Lyon, 103, Grande-Rue-de-la-Croix-Rousse, 69317 Lyon cedex 04, France; Centre des maladies trophoblastiques gestationnelles, centre hospitalier Lyon Sud, bâtiment 3B, 2(e) étage, 165, chemin du Grand-Revoyet, 69495 Pierre-Bénite, France.

Annales De Pathologie
|December 16, 2014
PubMed
Summary
This summary is machine-generated.

Gestational trophoblastic disease (GTD) encompasses rare pregnancy-related disorders. Early diagnosis and chemotherapy significantly improve outcomes for these conditions.

Keywords:
ChoriocarcinomaChoriocarcinomeGestational trophoblastic diseaseHydatiform moleMaladies gestationnelles trophoblastiquesMôle hydatiforme

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Area of Science:

  • Gynecology
  • Oncology
  • Pathology

Context:

  • Gestational trophoblastic disease (GTD) comprises a spectrum of pregnancy-related disorders.
  • Includes premalignant hydatiform moles and malignant gestational trophoblastic neoplasias.
  • Accurate diagnosis can be challenging, requiring correlation of histology, hCG levels, and imaging.

Purpose:

  • To provide an overview of gestational trophoblastic disease.
  • To highlight diagnostic challenges and management strategies.
  • To emphasize the importance of specialized care and registration.

Summary:

  • Gestational trophoblastic disease (GTD) includes hydatiform mole (premalignant) and gestational trophoblastic neoplasia (malignant).
  • Malignant forms include invasive mole, choriocarcinoma, placental site trophoblastic tumor, and epithelioid trophoblastic tumor.
  • Diagnosis relies on histological findings, serum hCG levels, and radiological assessment.
  • Chemotherapy has greatly improved prognosis.

Impact:

  • Improved understanding of GTD classification and diagnosis.
  • Highlights the critical role of chemotherapy in managing GTD.
  • Stresses the necessity of centralized management through national services for optimal patient outcomes.