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Affective symptoms and the overactive bladder - a systematic review.
Desiree Vrijens1, Jamie Drossaerts2, Gommert van Koeveringe1
1Department of Urology, Maastricht University Medical Centre, Maastricht, The Netherlands; Pelvic Care Centre Maastricht, Maastricht University Medical Centre, Maastricht, The Netherlands.
Journal of Psychosomatic Research
|December 16, 2014
Summary
This review found a link between overactive bladder syndrome (OAB) and affective conditions like depression and anxiety. Further research is needed to confirm causality and the strength of these associations.
Area of Science:
- Urology
- Psychiatry
- Evidence Synthesis
Background:
- Overactive bladder syndrome (OAB) involves urgency, frequency, and nocturia.
- Existing literature suggests a potential link between OAB and affective conditions such as depression and anxiety.
- A comprehensive systematic review on this association has been lacking.
Purpose of the Study:
- To systematically review and synthesize existing literature on the association between overactive bladder syndrome (OAB) and affective conditions.
- To provide a qualitative overview of the current evidence regarding the co-occurrence of OAB with depression and anxiety.
Main Methods:
- Conducted a systematic review adhering to PRISMA guidelines.
- Included 43 articles encompassing over 80,000 subjects.
- Assessed the quality of evidence using the GRADE framework.
Main Results:
- A positive association between depression and OAB was reported in 26 studies, and between anxiety and OAB in 6 studies.
- Longitudinal data indicated potential for new onset of OAB in depressive subjects (GRADE level 2) and OAB with anxiety (GRADE level 1).
- Evidence quality for OAB and depression co-occurrence was rated GRADE level 3.
Conclusions:
- This systematic review is the first to comprehensively overview the association between OAB and affective symptoms.
- While an association is evident, many studies lacked longitudinal data and causal evidence.
- Further research is required to elucidate the strength of the effect and establish causality.
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