Related Experiment Video

Updated: Apr 19, 2026

Phage Phenomics: Physiological Approaches to Characterize Novel Viral Proteins
09:40

Phage Phenomics: Physiological Approaches to Characterize Novel Viral Proteins

Published on: June 11, 2015

13.0K

A structured annotation frame for the transposable phages: a new proposed family "Saltoviridae" within the

Chantal Hulo1, Patrick Masson1, Philippe Le Mercier1

  • 1Swiss-Prot Group, Swiss Institute of Bioinformatics, Centre Médical Universitaire, CH-1211 Geneva 4, Switzerland.

Virology
|December 16, 2014
PubMed

Insights

Enterobacteriophage Mu, a transposable phage, has well-annotated proteins detailing its life cycle. This study proposes a new viral family, Saltoviridae, to classify these ubiquitous bacterial viruses.

Area of Science:

  • Virology
  • Microbiology
  • Bioinformatics

Background:

  • Enterobacteriophage Mu is a model transposable phage.
  • Transposable phages are temperate bacterial viruses with dsDNA genomes.
  • These phages infect various proteobacteria.

Purpose of the Study:

  • To detail Mu-encoded proteins and their roles in phage life cycles.
  • To describe conserved properties of sequenced transposable phages.
  • To propose a taxonomic reorganization of Caudovirales.

Main Methods:

  • Annotation of Mu-encoded proteins in UniProtKB.
  • Linking proteins to a controlled vocabulary for phage cycles.
  • Comparative analysis of sequenced transposable phage genomes.

Main Results:

  • Detailed annotation of Mu proteins and their functions.
  • Identification of conserved properties across 26 transposable phages.
  • Proposal for a new viral family, Saltoviridae, and subfamilies.

Conclusions:

  • The study provides a comprehensive understanding of transposable phages.
  • A new classification system, Saltoviridae, is proposed for these viruses.
  • This reorganization aids in understanding viral diversity and evolution.
Keywords:
CaudoviralesPhage protein annotationPhage taxonomy“Myosaltovirinae”“Saltoviridae”“Siphosaltovirinae”

More Related Videos

Precise Phage Mutagenesis with NgTET-Assisted CRISPR-Cas Systems10:52

Precise Phage Mutagenesis with NgTET-Assisted CRISPR-Cas Systems

Published on: October 14, 2025

1.4K
An Assay for Quantifying Protein-RNA Binding in Bacteria07:02

An Assay for Quantifying Protein-RNA Binding in Bacteria

Published on: June 12, 2019

7.1K

Related Concept Videos

DNA Bacteriophages01:26

DNA Bacteriophages

Bacteriophages, or phages, are viruses that specifically infect bacteria, utilizing their genetic material to hijack host cellular machinery for replication. DNA bacteriophages employ single-stranded DNA (ssDNA) or double-stranded DNA (dsDNA) genomes. These phages exhibit diverse replication strategies and host interactions, influencing their ecological roles and applications in biotechnology and medicine.ssDNA BacteriophagesssDNA phages, with their small genomes, utilize unique strategies to...
1.6K
Overview of Transposition and Recombination02:13

Overview of Transposition and Recombination

Transposons make up a significant part of genomes of various organisms. Therefore, it is believed that transposition played a major evolutionary role in speciation by changing genome sizes and modifying gene expression patterns. For example, in bacteria, transposition can lead to conferring antibiotic resistance. Movement of transposable elements within the genetic pool of pathogenic bacteria can aid in transfer of antibiotic-resistant genetic elements. In eukaryotes, transposons can carry out...
21.3K
DNA-only Transposons02:57

DNA-only Transposons

DNA-only transposons are called autonomous transposons since they code for the enzyme transposase that is required for the transposition mechanism. Insertion of transposons can alter gene functions in multiple ways. They can mutate the gene, alter gene expression by introducing a novel promoter or insulator sequence, introduce new splice sites, and change the mRNA transcripts produced, or remodel chromatin structure.
The donor site from where the transposon is excised is either degraded or...
19.0K
Transposons01:24

Transposons

Transposons, or "jumping genes," are small mobile genetic elements (MGEs) that range from 700 to 40,000 base pairs in length. They are found in all organisms and can move within the same chromosome or transfer to different chromosomes. In some cases, transposons can also jump between different host DNA molecules, such as plasmids or viruses, contributing to genetic variability.Barbara McClintock first discovered these mobile genetic elements in the 1940s while studying maize genetics, and she...
3.3K
Size and Structure of Viral Genomes01:26

Size and Structure of Viral Genomes

Viral genomes exhibit remarkable diversity in size, structure, and composition, influencing their replication strategies and interactions with host cells. These genomes consist of either DNA or RNA and may be linear or circular. Additionally, they can be single-stranded or double-stranded, with each configuration affecting how the virus propagates within a host. RNA viruses, for instance, generally have smaller genomes than DNA viruses, a factor that contributes to their high mutation rates and...
1.2K
Non-LTR Retrotransposons03:18

Non-LTR Retrotransposons

As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
14.1K