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NK/T cell lymphoma associated with peripheral eosinophilia
E Yap1, W F Wan Jamaluddin, N R Tumian
1Universiti Kebangsaan Malaysia Medical Centre, Cell Therapy Centre, Malaysia.
The Malaysian Journal of Pathology
|December 16, 2014
Summary
This case report details an aggressive NK/T cell lymphoma, nasal type, presenting outside the aerodigestive tract as a chest wall mass. The tumor showed a unique association with peripheral eosinophilia, fluctuating with treatment and disease activity.
Area of Science:
- Oncology
- Immunology
- Pathology
Background:
- NK/T cell lymphoma, nasal type, is an aggressive malignancy.
- Extranodal disease outside the aerodigestive tract is rare and behaves more aggressively.
- Conventional therapies are less effective for extranodal NK/T cell lymphoma.
Observation:
- A rare case of NK/T cell lymphoma, nasal type, presented as an anterior chest wall mass originating in the pectoralis muscle.
- The patient exhibited peripheral eosinophilia that correlated with disease activity.
- Eosinophilia levels fluctuated with surgical intervention and chemotherapy.
Findings:
- This is the third reported case of NK/T cell lymphoma associated with peripheral eosinophilia.
- The case suggests a link between specific NK cell subsets and eosinophilic activation in these lymphomas.
- Peripheral eosinophilia may serve as a marker for disease activity in NK/T cell lymphoma.
Implications:
- Further research into NK cell subsets is crucial for classifying NK/T cell lymphomas.
- Understanding the mechanisms of eosinophilic activation could lead to novel therapeutic strategies.
- This case expands the known clinical presentations of NK/T cell lymphoma, nasal type.
