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Relation between neutrophil-to-lymphocyte ratio and severity of coronary artery stenosis

G-Y Zhang1, M Chen1, Z-M Yu1

  • 1Department of Cardiology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.

Genetics and Molecular Research : GMR
|December 16, 2014
PubMed

Insights

The neutrophil-to-lymphocyte ratio (NLR) is higher in patients with severe coronary artery stenosis. This blood marker can help predict the severity of coronary heart disease.

Area of Science:

  • Cardiology
  • Hematology
  • Biomarkers

Background:

  • Coronary artery disease (CAD) poses a significant health burden.
  • Assessing the severity of coronary artery stenosis is crucial for patient management.
  • Novel biomarkers for predicting CAD severity are needed.

Purpose of the Study:

  • To investigate the relationship between the neutrophil-to-lymphocyte ratio (NLR) and the severity of coronary artery stenosis.
  • To determine if NLR can serve as a predictor for coronary artery disease severity.

Main Methods:

  • A total of 219 patients were enrolled, categorized into coronary artery atherosclerosis (CAC), stable angina pectoris (SAP), and acute coronary syndrome (ACS) groups.
  • Patients were classified into low-Gensini score (N=142) and high-Gensini score (N=77) groups based on coronary angiography.
  • Neutrophil-to-lymphocyte ratio (NLR) was calculated from complete blood count data. Correlation and logistic regression analyses were employed.

Main Results:

  • The NLR was significantly elevated in ACS patients compared to SAP and CAC patients (P < 0.05).
  • Patients in the high-Gensini score group exhibited higher NLRs than those in the low-Gensini score group (P < 0.05).
  • NLR showed a significant positive correlation with the Gensini score. High NLR, age, and low high-density lipoprotein were independent predictors of high Gensini scores.

Conclusions:

  • The neutrophil-to-lymphocyte ratio (NLR) is significantly associated with the severity of coronary artery stenosis.
  • NLR serves as an independent predictor for high Gensini scores, indicating severe coronary artery disease.
  • NLR may be a valuable and accessible biomarker for assessing coronary heart disease severity.

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