Related Experiment Video
Updated: Apr 19, 2026

High-throughput Identification of Synergistic Drug Combinations by the Overlap2 Method
Published on: May 21, 2018
Entry time effects and follow-on drug competition
Luiz Flavio Andrade1,2, Catherine Sermet3, Sylvain Pichetti4
1GATE-CNRS, University of Lyon 2, Lyon, France. andrade@gate.cnrs.fr.
First movers in the follow-on drug market capture and maintain larger market shares. This competitive advantage persists over time, unaffected by generic competition, highlighting the importance of early entry in pharmaceutical markets.
Area of Science:
- Pharmaceutical Economics
- Health Economics
- Innovation Economics
Background:
- Pharmaceutical R&D often focuses on follow-on drugs, sparking debate.
- Econometric analysis of follow-on drug competition is limited due to identification challenges.
Purpose of the Study:
- To investigate the impact of entry order on follow-on drug competition.
- To analyze the effects on market share for first entrants in the follow-on drug market.
- To assess how competitive advantages change over time.
Main Methods:
- Econometric analysis of the French pharmaceutical market (2001-2007).
- Examination of market share dynamics for follow-on drugs.
- Analysis of pricing strategies and innovation levels.
Main Results:
- First movers in the follow-on drug market capture and maintain greater market share.
- The market position of follow-on drugs is resilient to generic drug emergence.
- Market share is positively correlated with higher pricing power and the highest level of innovation.
Conclusions:
- Being first in the follow-on drug market confers a significant and lasting competitive advantage.
- Innovation level is a key factor in maximizing market share for follow-on drugs.
- Market power remains crucial for first movers in the pharmaceutical industry.
Related Concept Videos
Time Course of Drug Effect
Pharmacokinetic–Pharmacodynamic Relationship: Duration of Dose-Effect Relationship
Drug Concentration Versus Time Correlation
Two pivotal parameters are the minimum effective concentration (MEC) and the minimum toxic concentration (MTC). The MEC is the...
Factors Influencing Drug Absorption: Presystemic Elimination
First Pass Effect
Depending on the route of administration, drugs can be metabolized in the liver, intestine, lungs, and vasculature. Orally administered drugs are first absorbed through the...
Chronopharmacokinetics: Time-Dependent Pharmacokinetics
Time-dependent pharmacokinetics refers to non-cyclical changes in drug rate processes over a period of time. It can lead to nonlinear pharmacokinetics, where the relationship between drug concentration and time is not proportional. Non-cyclical...

