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Adiponectin gene polymorphisms contributes to ischemic stroke risk: A meta-analysis.

Dingzhu Shen1, Sanli Xing2, Chuan Chen2

  • 1Shanghai Geriatric Institute of Chinese Medicine, Longhua Hospital Affiliated Shanghai University of Traditional Chinese Medicine, P.R. China kongkong99099@163.com article_chenchuan@163.com.

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|December 16, 2014
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Adiponectin gene rs2241766 polymorphism is linked to increased ischemic stroke risk. This meta-analysis clarifies the association between adiponectin gene variants and stroke susceptibility.

Keywords:
Meta-analysisadiponectinischemic stroke

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Area of Science:

  • Genetics
  • Cardiovascular Disease
  • Epidemiology

Background:

  • Previous studies suggest a link between adiponectin gene polymorphisms and ischemic stroke risk, but findings are inconsistent.
  • Adiponectin plays a role in metabolic and cardiovascular health, making its genetic variations relevant to stroke etiology.

Purpose of the Study:

  • To conduct a meta-analysis to clarify the association between adiponectin gene polymorphisms and the risk of ischemic stroke.

Main Methods:

  • A comprehensive literature search was performed across multiple databases up to July 2013.
  • Included studies reported Odds Ratios (OR) and 95% Confidence Intervals (CI) for adiponectin polymorphisms and ischemic stroke.
  • The meta-analysis included 1720 stroke cases and 5549 controls.

Main Results:

  • The rs2241766 polymorphism in the adiponectin gene was significantly associated with an increased risk of ischemic stroke in a recessive model (GG vs. TT+TG).
  • No significant association was found between rs1501299 or rs266729 polymorphisms and ischemic stroke risk.

Conclusions:

  • The rs2241766 polymorphism of the adiponectin gene is associated with an increased risk of ischemic stroke.
  • Further research may explore the functional mechanisms underlying this genetic association.