Related Experiment Video
Updated: Apr 19, 2026
06:15
Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia
Published on: August 9, 2024
2.0K
Current status on histological classification in Cushing's disease.
Luis V Syro1, Fabio Rotondo, Michael D Cusimano
1Department of Neurosurgery, Hospital Pablo Tobon Uribe, Clinica Medellin and Group of Genetics, Regeneration and Cancer, Universidad de Antioquia, Medellín, Colombia, lvsyro@une.net.co.
Pituitary
|December 16, 2014
Summary
Histopathology aids Cushing's disease management by identifying pituitary tumor subtypes. Surgical tissue analysis is crucial for tailoring treatment, even if initial remission isn't achieved.
Area of Science:
- Endocrinology
- Neurosurgery
- Pathology
Background:
- Cushing's disease management presents ongoing challenges.
- Surgery is the primary treatment, offering high success rates.
- Morphological diagnosis of surgical tissue is vital for therapeutic adjustments.
Purpose of the Study:
- To present histopathological features in Cushing's disease.
- To characterize subtypes of ACTH-producing pituitary tumors.
- To discuss the significance of pituitary gland findings.
Main Methods:
- Literature search conducted using PubMed.
- Focus on pathology and Cushing's disease.
Main Results:
- Detailed histopathological features of the pituitary gland in Cushing's disease patients are presented.
- Recognition and characterization of various ACTH-producing pituitary tumor subtypes.
- Discussion on the implications of a normal pituitary gland, with or without Crooke's changes.
Conclusions:
- Histopathological analysis is key to understanding Cushing's disease subtypes.
- Tailoring treatment based on surgical tissue findings is essential.
- The significance of pituitary gland morphology in therapeutic decision-making is highlighted.
Related Concept Videos
01:26Cushing Syndrome I: Introduction
13
Cushing syndrome refers to the collection of clinical manifestations that arise when tissues are exposed to excessive amounts of cortisol or cortisol-like medications over an extended period. Cortisol, a glucocorticoid produced by the adrenal cortex, regulates metabolism, immune responses, and the body’s adaptation to stress. When its concentration remains chronically elevated, these physiological pathways become dysregulated, resulting in the characteristic features of the...
13
01:19Cushing Syndrome II: Pathophysiology
1
Cortisol production is normally governed by the hypothalamic–pituitary–adrenal (HPA) axis, which maintains hormonal balance through tightly regulated feedback mechanisms. Disruption of this regulatory system is central to the development of Cushing syndrome, whether the excess cortisol originates from external medications or internal pathology. Persistent cortisol elevation alters metabolism, immune function, and endocrine signaling, producing the characteristic clinical features...
1
01:19Cadherins in Tissue Organization
4.6K
The cadherins are a superfamily of cell adhesion molecules comprising over 180 variants, with specific tissues expressing a particular combination of cadherin types. Cadherins generally exhibit homophilic binding; i.e., cadherins on one cell bind to cadherins of the same or closely related type on another cell. Thus, cells of the same type have a specific affinity to bind to each other and sort themselves into clusters to form tissues.
Cell Sorting During Development
Cell sorting plays an...
Cell Sorting During Development
Cell sorting plays an...
4.6K
01:20Classification of Epithelial Tissues: Glandular Epithelium
20.0K
The glandular epithelium is made of one or more epithelial cells modified to synthesize and secrete chemical substances. Glandular epithelia can be classified based on cell number. Unicellular glands have individual secretory cells scattered across the epithelial monolayer. In contrast, multicellular glands consist of a hollow tubular duct attached to the cluster of secretory cells located in the deep pockets.
Multicellular glands are formed during early development when epithelial budding...
Multicellular glands are formed during early development when epithelial budding...
20.0K
01:29Cardiomyopathy III: Hypertrophic Cardiomyopathy
812
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
812
01:22Classification of Epithelial Tissues: Overview
31.1K
Epithelial tissues are classified according to the shape of the cells and the number of cell layers formed. Cell shapes can be squamous (flattened and thin), cuboidal (square-like, as wide as it is tall), or columnar (rectangular, taller than it is wide). Additionally, the nucleus shape helps identify the type of epithelial cells. Squamous cells have flattened disc-shaped nuclei, cuboidal cells have spherical nuclei, and columnar cells have elongated nuclei.
Based on the number of cell layers,...
Based on the number of cell layers,...
31.1K