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Food derived bioactive peptides and intestinal barrier function
Olga Martínez-Augustin1, Belén Rivero-Gutiérrez2, Cristina Mascaraque3
1Department of Biochemistry and Molecular Biology 2, CIBERehd, University of Granada, Instituto de Investigación Biosanitaria ibs, Granada 18071, Spain. omartine@ugr.es.
International Journal of Molecular Sciences
|December 16, 2014
Summary
Food-derived bioactive peptides show potential for enhancing intestinal barrier function (IBF). Further research is needed to identify specific peptides and their mechanisms for therapeutic applications.
Area of Science:
- Nutrition Science
- Gastroenterology
- Immunology
Background:
- Food-derived bioactive peptides are recognized for health benefits, acting as functional foods or nutraceuticals.
- The intestinal barrier function (IBF) is crucial for nutrient absorption and preventing pathogen entry.
- Dysfunctional IBF is linked to diseases like inflammatory bowel disease and metabolic syndrome.
Purpose of the Study:
- To review the effects of food-derived bioactive peptides on the components of the intestinal barrier function.
- To synthesize current knowledge on in vitro and in vivo studies of these peptides in both healthy and disease states.
Main Methods:
- Literature review of studies investigating food-derived bioactive peptides and their impact on intestinal barrier function.
- Analysis of in vitro and in vivo experimental data from healthy and diseased subjects.
Main Results:
- Food-derived bioactive peptides demonstrate a potential to influence the intestinal barrier function.
- Evidence suggests these peptides may modulate key components of the intestinal barrier, including the epithelium and immune cells.
Conclusions:
- Food-derived bioactive peptides hold promise for modifying IBF and potentially aiding in disease management.
- Further investigation is required to isolate specific bioactive peptides and elucidate their precise mechanisms of action for therapeutic development.
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