Related Experiment Video
Updated: Apr 19, 2026
Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
Published on: June 8, 2022
Resveratrol possesses protective effects in a pristane-induced lupus mouse model
Zhuo-Long Wang1, Xiao-Fang Luo1, Meng-Tao Li1
1Department of Rheumatology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China.
Resveratrol, a SIRT1 activator, shows protective effects against lupus in mice by reducing autoantibodies and kidney damage. This natural compound may offer a new treatment strategy for systemic lupus erythematosus (SLE).
Area of Science:
- Immunology
- Pharmacology
- Autoimmune Diseases
Background:
- Systemic lupus erythematosus (SLE) is a complex autoimmune disease with no satisfactory treatments.
- SIRT1 deficiency in mice leads to autoimmune conditions, including kidney damage and autoantibody production.
- Resveratrol, a SIRT1 activator, exhibits anti-inflammatory and immune-regulatory properties.
Purpose of the Study:
- To investigate the preventative effects of resveratrol in a pristane-induced lupus mouse model.
- To assess the immune-modulating impacts of resveratrol on lupus development.
Main Methods:
- Mice were induced with lupus using pristane and treated with varying doses of resveratrol for seven months.
- Serum autoantibodies were quantified, and spleen cells (including CD4+ T and CD19+ B cells) were analyzed in vitro using flow cytometry.
- Immune cell function, proliferation, apoptosis, and cytokine production were assessed.
Main Results:
- Resveratrol treatment reduced proteinuria, kidney immunoglobulin deposition, and glomerulonephritis in lupus mice.
- It attenuated serum IgG1 and IgG2a levels.
- Resveratrol suppressed T cell activation markers (CD69, CD71), proliferation, and Th1 cell populations while promoting T cell apoptosis. B cell antibody production and proliferation were also inhibited.
Conclusions:
- Resveratrol demonstrates significant protective effects in a mouse model of lupus.
- These findings suggest resveratrol as a potential novel therapeutic agent for managing systemic lupus erythematosus (SLE).
