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Association between 1019C/T polymorphism in the connexin 37 gene and dilated cardiomyopathy

J Tang1, L Li, L Q Hu

  • 1The Key Laboratory of Cardiovascular Remodeling and Function Research, Department of Cardiology, Shandong University, Qilu Hospital, Chinese Ministry of Education and Chinese Ministry of Health, Jinan, Shandong, China - guo13665103927@163.com.

Minerva Cardioangiologica
|December 16, 2014
PubMed

Insights

The connexin 37 (CX37) C allele is linked to increased dilated cardiomyopathy (DCM) risk in Chinese Han individuals. Female carriers of the CX37 C allele face a higher DCM risk than males.

Area of Science:

  • Genetics
  • Cardiology
  • Molecular Biology

Background:

  • Dilated cardiomyopathy (DCM) is a significant cardiovascular disease.
  • Genetic factors play a role in DCM susceptibility.
  • The connexin 37 (CX37) gene is implicated in cardiac function.

Purpose of the Study:

  • To investigate the association between the CX37 1019C/T polymorphism and DCM risk.
  • To determine if CX37 gene variations influence susceptibility to dilated cardiomyopathy in a Han Chinese population.

Main Methods:

  • A case-control study involving 873 DCM patients and 816 controls from China.
  • Genotyping of the CX37 1019C/T polymorphism using DNA sequencing.
  • Statistical analysis to compare allele and genotype frequencies between groups.

Main Results:

  • The CX37 C allele was significantly more frequent in DCM patients (57.33%) than in controls (42.03%).
  • Carriers of the C allele (CC+TC genotypes) had a 2.05-fold increased risk of DCM compared to TT homozygotes.
  • Stratified analysis revealed higher DCM risk for C allele carriers in both males (OR=1.64) and females (OR=2.32), with a more pronounced effect in females.

Conclusions:

  • The CX37 C allele is associated with an increased susceptibility to DCM in the Han Chinese population.
  • Female carriers of the CX37 C allele exhibit a greater risk for DCM compared to TT homozygotes than male carriers.
Abstract

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