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Role of gamma-delta (γδ) T cells in autoimmunity

Sourav Paul1, Shilpi1, Girdhari Lal2

  • 1National Centre for Cell Science, Pune University Campus, Pune, India.

Journal of Leukocyte Biology
|December 16, 2014
PubMed

γδ T cells represent a small population of overall T lymphocytes (0.5-5%) and have variable tissue distribution in the body. γδ T cells can perform complex functions, such as immune surveillance, immunoregulation, and effector function, without undergoing clonal expansion. Heterogeneous distribution and anatomic localization of γδ T cells in the normal and inflamed tissues play an important role in alloimmunity, autoimmunity, or immunity. The cross-talk between γδ T cells and other immune cells and phenotypic and functional plasticity of γδ T cells have been given recent attention in the field of immunology. In this review, we discussed the cellular and molecular interaction of γδ T cells with other immune cells and its mechanism in the pathogenesis of various autoimmune diseases.

Keywords:
Th17inflammationintraepithelial lymphocytemultiple sclerosis

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