Related Experiment Video

Updated: Apr 19, 2026

A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia
05:51

A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia

Published on: June 15, 2011

26.6K

Genetic overlap between antipsychotic response and susceptibility to schizophrenia

Masashi Ikeda1, Reiji Yoshimura, Ryota Hashimoto

  • 1Department of Psychiatry Fujita Health University School of Medicine Toyoake, Aichi, Japan ikeda-ma@fujita-hu.ac.jp Department of Psychiatry University of Occupational and Environmental Health Kitakyushu, Fukuoka, Japan Molecular Research Center for Children's Mental Development United Graduate School of Child Development Osaka University Osaka, Japan and Department of Psychiatry Graduate School of Medicine Osaka University Osaka, Japan Department of Psychiatry Fujita Health University School of Medicine Toyoake, Aichi, Japan Department of Psychiatry Graduate School of Medicine Osaka University Osaka, Japan Department of Psychiatry Teikyo University School of Medicine Itabashi, Tokyo, Japan Department of Psychiatry Sake Seijinkai Hospital Yokohama, Kanagawa, Japan Department of Human Genetics Graduate School of Medicine the University of Tokyo Bunkyo, Tokyo, Japan and Research Center for Hepatitis and Immunology National Center for Global Health and Medicine Ichikawa, Chiba, Japan Department of Human Genetics Graduate School of Medicine the University of Tokyo Bunkyo, Tokyo, Japan Laboratory of Health Education Graduate School of Education The University of Tokyo Bunkyo, Tokyo, Japan Department of Human Genetics Graduate School of Medicine the University of Tokyo Bunkyo, Tokyo, Japan Department of Psychiatry Graduate School of Medicine the University of Tokyo Bunkyo, Tokyo, Japan Department of Psychiatry Graduate School of Medicine Osaka University Osaka, Japan Department of Psychiatry University of Occupational and Environmental Health Kitakyushu, Fukuoka, Japan Department of Psychiatry Nagoya University Graduate School of Medicine Nagoya, Aichi, Japan Department of Psychiatry Fujita Health University School of Medicine Toyoake, Aichi, Japan.

Journal of Clinical Psychopharmacology
|December 16, 2014
PubMed
Abstract

No abstract available in PubMed .

More Related Videos

HSV-Mediated Transgene Expression of Chimeric Constructs to Study Behavioral Function of GPCR Heteromers in Mice07:30

HSV-Mediated Transgene Expression of Chimeric Constructs to Study Behavioral Function of GPCR Heteromers in Mice

Published on: July 9, 2016

7.7K
Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra05:14

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra

Published on: September 8, 2021

5.0K

Related Concept Videos

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
2.6K
Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
1.2K
Psychological and Sociocultural Causes of Schizophrenia01:29

Psychological and Sociocultural Causes of Schizophrenia

Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
967
Antipsychotic Drugs: Typical and Atypical Agents01:21

Antipsychotic Drugs: Typical and Atypical Agents

Antipsychotic drugs are classified into first-generation (typical) drugs including phenothiazines; and second-generation (atypical) drugs. Chlorpromazine hydrochloride (Thorazine), a phenothiazine derivative, broadly impacts the central, autonomic, and endocrine systems. This drug, along with typical agents like haloperidol (Haldol), primarily works by antagonizing D2 receptors, thus reducing dopaminergic neurotransmission. However, typical antipsychotics can cause side effects such as sedation...
1.3K
Psychosis and Antipsychotic Drugs: Overview01:28

Psychosis and Antipsychotic Drugs: Overview

The term "psychosis" refers to a spectrum of mental disorders characterized by abnormal thoughts, perceptions, and behaviors. It can manifest as mood disorders, dementia, delirium with psychotic features, substance-induced psychosis with psychotic features, brief psychotic disorder, delusional disorder, schizoaffective disorder, and schizophrenia. Among all these disorders, schizophrenia is the most common psychotic disorder, affecting 1% of the worldwide population. Psychotic...
1.2K
Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu01:29

Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu

Genetic variations significantly influence drug response through pharmacokinetics, receptor interactions, and biologic milieu modifications. Pharmacokinetic alterations impact drug metabolism and clearance, affecting efficacy and toxicity. Variants in drug-metabolizing enzymes, such as CYP2C9 and CYP2C19, alter drug activation and elimination. For example, CYP2C9 loss-of-function variants require lower warfarin doses to prevent excessive bleeding, while CYP2C19 variants reduce clopidogrel...
135