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Evaluation of a special combination of glucan with organic selenium derivative in different murine tumor models
Vaclav Vetvicka1, Marcos Felipe Pinatto-Botelho2, Alcindo A Dos Santos2
1Department of Pathology, University of Louisville, Louisville, KY, U.S.A. vaclav.vetvicka@louisville.edu.
Abstract:
β-glucans are well-established immunomodulators with strong effects resulting in slowing or even inhibiting cancer growth. Recent studies have repeatedly suggested that the biological activities of β-glucan can be potentiated by the addition of other bioactive agents. In the current study, we focused on the anticancer effects of a combination of yeast-derived β-glucan and a selenium-linked pseudodisaccharide. Using three different models of murine cancer, we showed that this combination strongly suppressed the growth of all three types of cancers, most likely via the interaction with natural anticancer antibodies.
Insights
This study shows that combining yeast-derived beta-glucans (β-glucans) with a selenium-linked pseudodisaccharide significantly inhibits cancer growth in mice. This potent combination likely works by activating natural anticancer antibodies.
Area of Science:
- Immunology
- Oncology
- Biochemistry
Background:
- Beta-glucans (β-glucans) are known immunomodulators that can inhibit cancer growth.
- Combining bioactive agents may potentiate the anticancer effects of β-glucans.
Purpose of the Study:
- To investigate the combined anticancer effects of yeast-derived β-glucan and a selenium-linked pseudodisaccharide.
- To evaluate the efficacy of this combination in different murine cancer models.
Main Methods:
- Utilized three distinct murine cancer models.
- Administered a combination of yeast-derived β-glucan and a selenium-linked pseudodisaccharide.
- Assessed tumor growth suppression.
Main Results:
- The combination therapy significantly suppressed the growth of all three tested murine cancers.
- Observed potentiation of anticancer activity compared to individual agents (implied).
Conclusions:
- The combination of yeast-derived β-glucan and selenium-linked pseudodisaccharide demonstrates strong anticancer properties.
- The mechanism of action likely involves interaction with natural anticancer antibodies.
