Related Experiment Video
Updated: Apr 19, 2026

Cell Type-specific Gene Expression Profiling in the Mouse Liver
Published on: September 17, 2019
Developmental programming of long non-coding RNAs during postnatal liver maturation in mice
Lai Peng1, Ariel Paulson2, Hua Li2
1Department of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, Storrs, Connecticut, United States of America.
Postnatal liver development involves significant changes, with long non-coding RNAs (lncRNAs) playing a key role. These lncRNAs and their neighboring genes show distinct expression patterns, influencing liver maturation processes.
Area of Science:
- Developmental Biology
- RNA Biology
- Genomics
Background:
- The liver performs vital functions, but its maturation occurs postnatally.
- Understanding the regulation of postnatal liver development is crucial.
- Long non-coding RNAs (lncRNAs) are implicated in organ development and cell differentiation.
Purpose of the Study:
- To investigate the role of lncRNAs in mouse liver maturation.
- To identify lncRNA expression dynamics during postnatal liver development.
Main Methods:
- RNA-Sequencing of mouse liver from perinatal to adult stages.
- Transcriptome analysis of coding and non-coding RNAs.
- Gene Ontology (GO) analysis to determine functional enrichment.
Main Results:
- Approximately 2,000 lncRNAs were identified in the developing mouse liver.
- Both coding and lncRNAs exhibited distinct temporal expression patterns (neonatal, adolescent, adult).
- lncRNAs and neighboring protein-coding genes displayed correlated expression, with neonatal lncRNAs linked to proliferation and immune processes, and adolescent lncRNAs to metabolism.
Conclusions:
- Postnatal liver development involves significant functional transitions regulated by lncRNAs.
- lncRNAs are potentially critical regulators of liver maturation.
- Correlated expression of lncRNAs and protein-coding genes suggests coordinated regulatory mechanisms.
More Related Videos
04:29Efficient Gene Knockdown in the Liver via Intrasplenic Injection of Adeno-Associated Virus Serotype 8 (AAV8)-Delivered Small Hairpin RNA
Published on: November 1, 2024
12:12In vivo Reprogramming of Adult Somatic Cells to Pluripotency by Overexpression of Yamanaka Factors
Published on: December 17, 2013
Related Concept Videos
lncRNA - Long Non-coding RNAs
lncRNA - Long Non-coding RNAs
Cell Specific Gene Expression
Formation of Muscle Fibers from Myoblasts
Muscle progenitor cells (MPCs) are formed from the myotomes. MPCs express genes that encode the transcription factors Pax3 and Pax7. Along with Pax 3/7, other transcription...
Liver Regeneration
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...