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Oxidative stress in benign prostatic hyperplasia: a systematic review
Paola Lucia Minciullo1, Antonino Inferrera, Michele Navarra
1Operative Unit of Allergy and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Messina, Italy.
Urologia Internationalis
|December 16, 2014
Summary
Oxidative stress (OS) is linked to benign prostatic hyperplasia (BPH) and prostate cancer. Lower antioxidant activity in BPH patients suggests a role for antioxidants in disease prevention and progression.
Area of Science:
- Urology
- Oncology
- Biochemistry
Background:
- Benign prostatic hyperplasia (BPH) development is associated with inflammatory mediators, hormones, diet, genes, and oxidative stress (OS).
- Prostate tissue damage and OS can trigger compensatory cellular proliferation, leading to hyperplastic growth.
Purpose of the Study:
- To review the role of oxidative stress and antioxidants in benign prostatic hyperplasia (BPH).
- To explore the potential of antioxidants in preventing BPH progression to prostate cancer.
Main Methods:
- A literature search of MEDLINE was conducted for articles published up to March 2014.
- Keywords used included 'oxidative stress', 'antioxidants', and 'benign prostatic hyperplasia'.
Main Results:
- Prostatic inflammation generates free radicals, and reduced antioxidant defenses can worsen oxidative damage.
- Imbalances between OS and antioxidant components are implicated in prostate diseases.
- BPH patients exhibit depleted antioxidant substances and elevated oxidant products.
- Higher OS and lower antioxidant activity are observed in prostate cancer compared to BPH and control groups, suggesting BPH as a premalignant condition.
Conclusions:
- Further research is necessary to elucidate the role of antioxidants in managing BPH.
- Antioxidants may hold potential for preventing the progression of BPH to prostate cancer.
