Related Experiment Video

Updated: Apr 19, 2026

Assessing Endothelial Vasodilator Function with the Endo-PAT 2000
07:46

Assessing Endothelial Vasodilator Function with the Endo-PAT 2000

Published on: October 15, 2010

44.7K

Predictive value of endothelial function by noninvasive peripheral arterial tonometry for coronary artery disease

Yasushi Matsuzawa1, Jing Li, Tatsuo Aoki

  • 1aDivision of Cardiovascular Diseases bBiomedical Statistics and Informatics cDivision of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, USA.

Coronary Artery Disease
|December 16, 2014
PubMed

Insights

Peripheral endothelial function, measured by reactive hyperemia-peripheral arterial tonometry (RH-PAT), improves cardiovascular disease risk prediction. This non-invasive test adds value beyond traditional risk factors for identifying coronary artery disease (CAD).

Area of Science:

  • Cardiology
  • Vascular Biology
  • Medical Diagnostics

Background:

  • Endothelial dysfunction is a critical factor in atherosclerosis and cardiovascular disease development.
  • Assessing peripheral endothelial function may offer new insights into cardiovascular risk.
  • Reactive hyperemia-peripheral arterial tonometry (RH-PAT) is a non-invasive method to evaluate endothelial function.

Purpose of the Study:

  • To determine if peripheral endothelial function assessed by RH-PAT provides additional clinical value for predicting coronary artery disease (CAD).
  • To evaluate the utility of RH-PAT in risk stratification beyond traditional cardiovascular risk factors.

Main Methods:

  • 118 patients undergoing coronary angiography were studied.
  • Fingertip reactive hyperemia-peripheral arterial tonometry (RH-PAT) was used to measure the RH-PAT index (Ln_RHI) before catheterization.
  • Coronary artery disease (CAD) was defined by significant stenosis or fractional flow reserve.

Main Results:

  • Patients with CAD had significantly lower Ln_RHI levels compared to those without CAD (P<0.001).
  • Ln_RHI was independently associated with CAD, even after accounting for traditional risk factors (OR=1.25, P=0.01).
  • Adding Ln_RHI to traditional risk factors significantly improved risk reclassification (NRI=0.62, P=0.001).

Conclusions:

  • Peripheral endothelial function measured by RH-PAT enhances risk stratification for CAD.
  • RH-PAT shows potential as a valuable tool for identifying high-risk patients for coronary artery disease.
Abstract

More Related Videos

Non-invasive Assessment of Microvascular and Endothelial Function05:41

Non-invasive Assessment of Microvascular and Endothelial Function

Published on: January 29, 2013

16.8K
Measuring the Carotid to Femoral Pulse Wave Velocity Cf-PWV to Evaluate Arterial Stiffness05:51

Measuring the Carotid to Femoral Pulse Wave Velocity Cf-PWV to Evaluate Arterial Stiffness

Published on: May 3, 2018

18.9K

Related Concept Videos

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
718
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
650
Assessment of blood pressure in brachial artery(two-step method)01:23

Assessment of blood pressure in brachial artery(two-step method)

Measuring blood pressure is a fundamental skill in healthcare that aids in diagnosing and monitoring hypertension and other cardiovascular conditions. An aneroid sphygmomanometer, commonly used in clinical settings, offers a manual and precise method for blood pressure measurement. The technique for using this instrument involves specific steps that must be carefully executed to ensure accuracy. The following detailed description outlines a two-step technique for assessing blood pressure using...
2.1K
Sensitivity, Specificity, and Predicted Value01:13

Sensitivity, Specificity, and Predicted Value

In healthcare diagnostics, laboratory tests play a crucial role in identifying and diagnosing a wide range of medical conditions. However, interpreting test results is not always straightforward. An abnormal test result does not always confirm the presence of a disease, just as a normal result does not guarantee its absence. To assess the reliability of these diagnostic tools, healthcare practitioners rely on two key statistical indicators: sensitivity and specificity.
Sensitivity is the...
1.9K