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Interaction of Salicylates and the Other Nonsteroidal Anti-Inflammatory Agents With Breast Cancer Endocrine

Eugenia Ch Yiannakopoulou1

  • 1Department of Medical Laboratories, Faculty of Health and Caring Professions, Technological Educational Institute of Athens, Athens, Greece.

American Journal of Clinical Oncology
|December 16, 2014
PubMed

Insights

Combining breast endocrine therapy with nonsteroidal anti-inflammatory drugs (NSAIDs) like aspirin and celecoxib shows a synergistic antitumor effect. This approach may improve treatment for estrogen-responsive breast cancer and aid in chemoprevention.

Area of Science:

  • Oncology
  • Pharmacology

Background:

  • High breast cancer mortality persists despite treatment advances.
  • Novel strategies are needed for chemoprevention and treating receptor-negative breast cancer.

Purpose of the Study:

  • To systematically review evidence on the synergistic antitumor effects of combining breast cancer endocrine treatment with salicylates and other nonsteroidal anti-inflammatory drugs (NSAIDs).

Main Methods:

  • Systematic review of electronic databases using relevant search terms.
  • Analysis of studies investigating exemestane with celecoxib, tamoxifen with celecoxib, and exemestane with aspirin.

Main Results:

  • Most studies investigated the combination of exemestane and celecoxib across various clinical settings.
  • Synergistic antitumor effects were detected in the majority of the reviewed studies.
  • Limited experimental studies explored tamoxifen with celecoxib and exemestane with aspirin.

Conclusions:

  • Limited evidence suggests a synergistic interaction between NSAIDs and endocrine therapy for estrogen-responsive breast cancer.
  • This combination may have clinical implications for reversing endocrine resistance and for breast cancer chemoprevention.

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