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Updated: Apr 19, 2026

Quantitative Autonomic Testing
Published on: July 19, 2011
Diagnosis and management of autonomic failure in neurodegenerative disorders
Luisa Sambati1, Giovanna Calandra-Buonaura, Andrea Doria
1IRCCS Institute of Neurological Sciences of Bologna, University of Bologna, Italy.
Background:
One of the hallmarks of the α-synucleinopathies is the degeneration of the autonomic nervous system.
Summary:
This review discusses the diagnosis and management of cardiovascular autonomic failure within the context of the α-synucleinopathies. In addition, it outlines the utility of various laboratory assessments including cardiovascular reflex tests for the differential diagnoses of these disorders, as well as general disease management strategies. Key Messages: Laboratory investigations assessing the autonomic control of the cardiovascular system are useful in the differential diagnosis of α-synucleinopathies, especially in early stages of disease.
Clinical Implications:
The characterization of the different features of AF in patients with α-synucleinopathies is challenging because it might help to improve the accuracy of the differential diagnosis between these diseases at onset. Further cardiovascular AF has been demonstrated to have a negative prognostic role in α-synucleinopathies, therefore an early detection of cardiovascular dysautonomia allows to positively impact the disease course guiding the appropriate therapy.
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