Related Experiment Video

Updated: Apr 19, 2026

A High-throughput Platform for the Screening of Salmonella spp./Shigella spp.
06:55

A High-throughput Platform for the Screening of Salmonella spp./Shigella spp.

Published on: November 7, 2018

9.6K

Global invasive bacterial vaccine-preventable diseases surveillance--2008-2014

Jillian Murray, Mary Agócs, Fatima Serhan

    MMWR. Morbidity and Mortality Weekly Report
    |December 16, 2014
    PubMed

    Insights

    Pneumococcal conjugate vaccines (PCV) significantly reduce childhood meningitis and pneumonia deaths. Global introduction of PCV is ongoing, with surveillance guiding its impact and implementation for child health.

    Area of Science:

    • Pediatrics
    • Infectious Diseases
    • Vaccinology

    Background:

    • Meningitis and pneumonia caused by Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae are major global child health threats.
    • Streptococcus pneumoniae was a leading cause of death in children under five before the introduction of pneumococcal conjugate vaccines (PCV).

    Purpose of the Study:

    • To highlight the global impact of PCV on reducing childhood morbidity and mortality.
    • To emphasize the importance of surveillance in guiding PCV introduction and monitoring its effectiveness.

    Main Methods:

    • Review of global health data concerning childhood infections and vaccine introduction.
    • Analysis of World Health Organization (WHO) and Gavi, the Vaccine Alliance recommendations and implementation data.

    Main Results:

    • PCV is recommended by the WHO for global childhood immunization programs, particularly in high child mortality regions.
    • As of November 2014, 58% of WHO member states had introduced PCV.
    • Invasive pneumococcal disease (IPD) and syndromic surveillance are crucial for informing PCV policy and assessing impact.

    Conclusions:

    • PCV introduction is critical for reducing the burden of pneumococcal disease in children worldwide.
    • Continued surveillance is essential for optimizing PCV strategies and maximizing public health benefits.

    More Related Videos

    Opsono-Adherence Assay to Evaluate Functional Antibodies in Vaccine Development Against Bacillus anthracis and Other Encapsulated Pathogens13:47

    Opsono-Adherence Assay to Evaluate Functional Antibodies in Vaccine Development Against Bacillus anthracis and Other Encapsulated Pathogens

    Published on: May 19, 2020

    3.9K
    Following in Real Time the Impact of Pneumococcal Virulence Factors in an Acute Mouse Pneumonia Model Using Bioluminescent Bacteria11:32

    Following in Real Time the Impact of Pneumococcal Virulence Factors in an Acute Mouse Pneumonia Model Using Bioluminescent Bacteria

    Published on: February 23, 2014

    15.8K

    Related Concept Videos

    Principles of Disease Surveillance01:26

    Principles of Disease Surveillance

    Disease surveillance is the systematic collection, analysis, and interpretation of health data essential to the planning, implementation, and evaluation of public health practice. This process integrates data dissemination to entities responsible for preventing and controlling disease, injury, and disability. Surveillance systems provide crucial information for action, helping public health authorities make informed decisions to manage and prevent outbreaks, ensure public safety, optimize...
    836
    Vaccinations01:51

    Vaccinations

    Overview
    54.7K
    Healthcare Associated Infections II: Preventive Measures01:22

    Healthcare Associated Infections II: Preventive Measures

    Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
    The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
    5.0K
    Infectious Diseases and Their Occurrence01:28

    Infectious Diseases and Their Occurrence

    Infectious diseases appear in populations through various transmission patterns, influenced by pathogen characteristics, population immunity, environmental conditions, and social behavior. Understanding these patterns is essential for effective public health surveillance and intervention. These categories—sporadic, outbreak, epidemic, pandemic, and endemic—help frame the nature and scope of disease events.Sporadic diseases occur irregularly and infrequently, without a predictable...
    74
    Bacterial Gastroenteritis01:18

    Bacterial Gastroenteritis

    Bacterial gastroenteritis, characterized by diarrhea, abdominal cramps, and vomiting, is often caused by ingestion of contaminated food or water and is frequently associated with pathogenic Escherichia coli strains. These microbes exploit two principal mechanisms to inflict disease.Shiga toxin–producing E. coli, also referred to as STEC—notably O157:H7—release Shiga toxins that target ribosomes, blocking protein synthesis. The B subunit of the toxin binds the host glycolipid...
    70
    Investigation of Disease Outbreaks01:23

    Investigation of Disease Outbreaks

    Multistate foodborne outbreaks pose significant public health risks and require meticulous investigation to identify sources and implement control measures. The Centers for Disease Control and Prevention (CDC) utilizes a dynamic seven-step process for these investigations, integrating data from laboratories, interviews, and environmental assessments to protect public health.Outbreak Detection: The detection of multistate outbreaks typically begins with PulseNet, the CDC's national laboratory...
    68