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Intercellular adhesion molecule-1 K469E polymorphism and risk of coronary artery disease: a meta-analysis
Shengqiang Zou1, Xin Pan2, Zhigang Chen2
1School of Medicine, Jiangsu University, Zhenjiang, China (mainland).
Insights
The Intercellular Adhesion Molecule-1 (ICAM-1) K469E polymorphism is linked to coronary artery disease (CAD) susceptibility. This meta-analysis confirms ICAM-1 K469E as a significant risk factor for CAD across diverse populations.
Area of Science:
- Genetics and Cardiovascular Disease
- Molecular Biology
- Population Genetics
Background:
- Intercellular Adhesion Molecule-1 (ICAM-1) K469E polymorphism is investigated for its role in coronary artery disease (CAD) susceptibility.
- Previous studies on the ICAM-1 K469E polymorphism and CAD association yielded conflicting results.
- A comprehensive meta-analysis was performed to resolve discrepancies and assess the overall association.
Purpose of the Study:
- To evaluate the association between the ICAM-1 K469E polymorphism and the risk of developing coronary artery disease (CAD).
- To synthesize evidence from multiple case-control studies to provide a robust conclusion on the genetic risk conferred by this polymorphism.
Main Methods:
- A systematic literature search was conducted across major databases (PubMed, EMBASE, CNKI, Weipu).
- Data from 15 case-control studies, comprising 3088 cases and 3466 controls, were analyzed.
- Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using a random-effects model to assess the strength of association.
Main Results:
- A significant association was found between the ICAM-1 K469E polymorphism and CAD under the dominant model (OR=1.80).
- Subgroup analyses revealed significant associations in both Asian (OR=1.92) and Caucasian (OR=1.64) populations.
- The polymorphism was also significantly associated with CAD risk in both younger (OR=1.46) and older (OR=1.92) patient groups.
Conclusions:
- The ICAM-1 K469E polymorphism is a confirmed risk factor for coronary artery disease (CAD).
- This genetic variant contributes to CAD susceptibility across different ethnic groups and age demographics.
- The findings support the clinical relevance of ICAM-1 K469E polymorphism in cardiovascular risk assessment.
Background:
Intercellular adhesion molecule-1 (ICAM-1) K469E polymorphism has been implicated in susceptibility to coronary artery disease (CAD). Several studies investigated the association of this polymorphism with CAD in different populations but the results were contradictory. A meta-analysis was conducted to assess the association between ICAM-1 K469E polymorphism and CAD susceptibility.
Material And Methods:
Databases including PubMed, EMBASE, China National Knowledge Infrastructure (CNKI), and Weipu Database were searched to find relevant studies. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of associations. A random-effects model was used.
Results:
Fifteen case-control studies including 3088 cases and 3466 controls were included. Overall, a significant association between ICAM-1 K469E polymorphism and CAD was observed in the dominant model (OR=1.80; 95% CI 1.62-2.01; P<0.00001; Pheterogeneity=0.40). In subgroup analysis by ethnicity, a significant association was found among Asians (OR=1.92; 95% CI 1.51-2.43; P<0.00001; Pheterogeneity=0.98) and among Caucasians (OR=1.64; 95% CI 1.30-2.08; P<0.0001; Pheterogeneity=0.04). In the subgroup analysis by age, a significant association was found among young patients (OR=1.46; 95% CI 1.10-1.93; P=0.008; Pheterogeneity=0.21) and old patients (OR=1.92; 95% CI 1.75-2.10; P<0.00001; Pheterogeneity=0.99). Conclusions Results of this meta-analysis suggest that ICAM-1 K469E polymorphism confers a risk factor of CAD.
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