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Updated: Apr 19, 2026
Creation of Abdominal Adhesions in Mice
Published on: August 27, 2016
Effect of intraperitoneal curcumin instillation on postoperative peritoneal adhesions
Ahmet Türkoğlu1, Mesut Gül, Hatice Kurt Yuksel
1Department of General Surgery, Faculty of Medicine, Dicle University, Diyarbakır,Turkey.
Objective:
The aim of this study was to determine the effect of curcumin on adhesion formation in a rat cecum abrasion model.
Materials And Methods:
Thirty Wistar rats were randomized into three groups; the control group received saline, the curcumin group received 10 mg/kg of curcumin after cecal abrasion, and in the sham group the abdominal wall was closed without any abrasion to the cecum. On day 15, adhesions were assessed blindly using a standardized scale, and histopathological samples were taken and examined.
Results:
There were no incisional hernias or wound dehiscences in any animals of the three groups. A comparison of adhesion scores showed a significant difference between the curcumin (median = 1) and the control group (median = 2; p < 0.05). The grade of inflammation of the curcumin (median = 1) and the sham (median = 0) group was significantly lower than that of the control group (median = 3; p < 0.01 and p < 0.001, respectively). Hydroxyproline levels were significantly lower in the sham (48.3 ± 11.8 µg/mg) and the curcumin (63.8 ± 13.9 µg/mg) group compared to the control group (85.7 ± 22.1 µg/mg; p < 0.05).
Conclusion:
These data suggest that curcumin, administered intraperitoneally, was effective in the prevention of peritoneal adhesion formation.
