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Updated: Apr 19, 2026
07:13
Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform
Published on: April 12, 2021
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[Lipocalin and kidney transplant].
Summary
Urinary neutrophil gelatinase-associated lipocalin (uNGAL) does not reliably predict delayed graft function (DGF) after kidney transplantation. Further research is needed to identify early DGF predictors in transplant recipients.
Area of Science:
- Nephrology
- Transplantation Immunology
- Biomarker Research
Background:
- Delayed graft function (DGF) is a common complication following kidney transplantation.
- DGF is associated with adverse outcomes, including increased rejection, prolonged hospitalization, and reduced long-term graft survival.
- Urinary neutrophil gelatinase-associated lipocalin (uNGAL) is recognized as a marker for acute kidney injury.
Purpose of the Study:
- To investigate the potential of urinary neutrophil gelatinase-associated lipocalin (uNGAL) as an early predictor of delayed graft function (DGF) in kidney transplant recipients.
- To evaluate the association between day 1 post-transplantation uNGAL levels and the occurrence of DGF.
Main Methods:
- A preliminary study involving 20 renal transplant recipients.
- Urine samples collected on day 1 post-transplantation to measure 24-hour urinary NGAL and creatinine excretion.
- Routine blood chemistry assessed on the same day.
Main Results:
- Delayed graft function (DGF) was observed in 6 out of 20 patients.
- No significant difference was found in 24-hour urinary NGAL excretion between patients with and without DGF (p<0.20).
- Age, reduced 24-hour urine output, and lower urinary creatinine excretion were associated with DGF in univariate and multivariate analyses.
Conclusions:
- This preliminary study indicates that 24-hour urinary NGAL excretion measured one day after kidney transplantation is not a reliable predictor of DGF.
- Larger studies with extended observation periods are necessary to validate these findings and explore other potential biomarkers.
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