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Related Concept Videos

Blood Transfusion01:15

Blood Transfusion

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Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
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Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

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Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
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Hemodialysis II: Procedure and Complications01:24

Hemodialysis II: Procedure and Complications

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DialyzersA hemodialysis (HD) dialyzer is a plastic cartridge containing thousands of parallel hollow fibers, which serve as semipermeable membranes. These fibers are typically made from cellulose-based or other synthetic materials. During HD, blood is pumped into the top of the cartridge and distributed among these fibers. Simultaneously, dialysis fluid, known as dialysate, is introduced into the bottom of the cartridge, bathing the outside of the fibers. Across the semipermeable membrane,...
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Hypersensitivity Reactions: Cytolytic Reactions01:01

Hypersensitivity Reactions: Cytolytic Reactions

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Type II hypersensitivity involves IgG and IgM antibodies targeting cell surface antigens, leading to cell destruction. This can occur through complement activation, antibody-dependent cell-mediated cytotoxicity (ADCC), or acting as opsonins for phagocytosis. When excessive, these reactions cause significant tissue damage.Drug-induced hemolytic anemia is a common example, where drugs like penicillin or cephalosporins bind to red blood cells, forming drug-protein complexes. These complexes...
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Tissue Transplantation01:24

Tissue Transplantation

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Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
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Drug Toxicity: Overview01:00

Drug Toxicity: Overview

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Drug toxicity quantifies the harm a compound causes to an organism, varying by dose and potentially impacting whole systems or specific organs like the liver. Toxic reactions may arise from venomous insect or spider bites, with effects ranging from mild symptoms to severe outcomes such as brain damage or death. Common forms of acute poisoning include ethanol intoxication and overdose of pain or fever medications, with substances like GHB and heroin being particularly lethal at doses close to...
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Related Experiment Video

Updated: Apr 19, 2026

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
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Adverse effects of transfusion.

Radhika Dasararaju1, Marisa B Marques

  • 1Department of Pathology, University of Alabama at Birmingham, 35249, USA. mmarques@uab.edu.

Cancer Control : Journal of the Moffitt Cancer Center
|December 16, 2014
PubMed
Summary

Transfusions are vital for cancer patients but carry significant risks of acute and delayed adverse events. Oncologists must carefully weigh the necessity of transfusions to minimize potential harm.

Area of Science:

  • Oncology
  • Transfusion Medicine

Background:

  • Patients with malignancy require transfusions, often long-term.
  • This patient group faces increased risks for transfusion-related adverse events.

Purpose of the Study:

  • To review the risks and complications associated with blood transfusions in cancer patients.
  • To emphasize the importance of judicious transfusion practices in oncology.

Main Methods:

  • Literature search of PubMed for original studies and reviews.
  • Summarization of findings complemented by clinical experience.

Main Results:

  • Deadly complications include transfusion-related acute lung injury, circulatory overload, and hemolytic reactions.
  • Common reactions like febrile or allergic responses cause discomfort and waste blood products.

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  • Long-term risks include graft-vs-host disease, alloimmunization, immunomodulation, and iron overload.

    • Conclusions:

    • All transfusions carry immediate and delayed risks.
    • Oncologists should transfuse cancer patients only when strictly necessary.