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Updated: Apr 19, 2026
A Multiplexed Luciferase-based Screening Platform for Interrogating Cancer-associated Signal Transduction in Cultured Cells
Published on: July 3, 2013
A single institution experience in compliance with universal screening for Lynch syndrome in colorectal cancer
Amy L Hill1, Kirandeep K Sumra, Marcia M Russell
1Department of Surgery, David Geffen School of Medicine, University of California at Los Angeles, 10833 Le Conte Ave, 72-247 CHS, Los Angeles, CA, 90095, USA.
Background:
Detection of Lynch syndrome has the potential to reduce morbidity and mortality among patients and their family members due to beneficial screening and treatment options. Several institutions have begun to adopt universal rather than risk-stratified screening protocols, but the lack of 100 % compliance rates requires identification of system-level interventions to improve screening practices.
Objective:
We aimed to identify patient, tumor, and system factors associated with lack of screening and identify system-based interventions to improve Lynch syndrome screening.
Design And Settings:
This study is a retrospective analysis of Lynch syndrome screening among colorectal cancer patients undergoing surgery in a single healthcare system.
Patients:
Two hundred and sixty-two patients who underwent surgery for colorectal cancer were studied.
Main Outcome Measures:
Rate of Lynch syndrome screening.
Results:
We identified that 75 % of the total cohort was screened for Lynch syndrome. Of patients under the age of 50, 78 % percent were screened. Lower screening rates were found among patients with complete pathologic tumor response and lower pathologic stage of tumor. Higher screening rates were found at the academic hospital and with colorectal surgeons. In multivariable logistic regression analysis, lower screening rates were associated with community hospital location (OR, 0.22; 95 % CI, 0.08-0.56).
Limitations:
Results may not be generalizable to different hospital settings.
Conclusions:
Several potential system-level interventions were identified to improve screening rates including an emphasis on improved provider communication.
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