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Updated: Apr 19, 2026

Induction and Clinical Scoring of Chronic-Relapsing Experimental Autoimmune Encephalomyelitis
Published on: July 4, 2007
Cryptococcal meningoencephalitis relapse after an eight-year delay: an interplay of infection and immune
Juri Katchanov1, Cristiane Blechschmidt2, Kirsten Nielsen3
1Department of Infectious Diseases and Gastroenterology, Vivantes Auguste-Viktoria-Klinikum, Berlin, Germany juri.katchanov@icloud.com.
Abstract:
We report a case of a symptomatic relapse of HIV-related cryptococcal meningoencephalitis eight years after the first diagnosis on the background of immune reconstitution. The findings as well as the clinical course suggests a combination of smouldering localised infection and enhanced inflammatory reaction related to immune restoration due to antiretroviral therapy. A combination of antifungal and anti-inflammatory therapy resulted in clinical and radiological improvement. Our case challenges the concept that immune reconstitution inflammatory syndrome and microbiological relapse are dichotomous entities.
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