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Related Experiment Video

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Forced Flowering in Mandarin Trees under Phytotron Conditions
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Jasmine flower extract lowers prolactin.

Philip Finny1, Charles Stephen2, Rajesh Jacob3

  • 1Registrar, Department of Endocrinology, Christian Medical College, Vellore, India philip.finny@gmail.com.

Tropical Doctor
|December 16, 2014
PubMed
Summary

Intranasal jasmine flower extract (JFE) shows promise in reducing elevated prolactin levels in patients taking antipsychotic medications. This natural remedy offers a potentially effective and cost-efficient alternative to traditional treatments.

Keywords:
Jasmine flower extractantipsychotic medicationhyperprolactinaemia

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Area of Science:

  • Endocrinology
  • Pharmacology
  • Herbal Medicine

Background:

  • Antipsychotic medications commonly cause hyperprolactinemia, leading to amenorrhea and galactorrhea.
  • Topical jasmine flower applications have previously demonstrated efficacy comparable to bromocriptine in managing lactation.

Purpose of the Study:

  • To assess the efficacy and safety of intranasal jasmine flower extract (JFE) for reducing prolactin levels.
  • To evaluate JFE as a potential treatment for antipsychotic-induced hyperprolactinemia.

Main Methods:

  • A randomized, double-blind, crossover clinical trial was conducted.
  • An aqueous-ethanol extract of jasmine flowers was administered as nasal drops.
  • A significant prolactin reduction was defined as ≥25 ng/mL.

Main Results:

  • Ten of 35 women experienced a significant decrease in serum prolactin with JFE treatment.
  • Non-response to JFE was associated with higher antipsychotic drug dosages.
  • The primary side effect was a mild, transient nasal burning sensation.
  • Cost analysis indicated JFE was more favorable than dopamine agonists.

Conclusions:

  • Jasmine flower extract contains a substance with prolactin-lowering properties.
  • Further research is needed to characterize the active compound in JFE.
  • Intranasal JFE presents a potential therapeutic option for managing hyperprolactinemia.