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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Related Experiment Video

Updated: Apr 19, 2026

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors
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Published on: September 20, 2016

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Non-small cell lung cancer, version 1.2015.

David S Ettinger, Douglas E Wood, Wallace Akerley

    Journal of the National Comprehensive Cancer Network : JNCCN
    |December 16, 2014
    PubMed
    Summary
    This summary is machine-generated.

    This NCCN Guidelines update details radiation therapy (RT) principles for Non-Small Cell Lung Cancer (NSCLC), covering general strategies, dose constraints, and planning for all stages. Multidisciplinary team input is crucial for optimal treatment decisions.

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    Detection of Targetable Alterations in Non-small Cell Lung Cancer using Next-generation Sequencing
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    Area of Science:

    • Oncology
    • Radiation Oncology

    Background:

    • Non-Small Cell Lung Cancer (NSCLC) requires precise radiation therapy (RT) planning.
    • NCCN Clinical Practice Guidelines provide essential standards for cancer care.

    Purpose of the Study:

    • To outline the core principles of radiation therapy for all stages of Non-Small Cell Lung Cancer (NSCLC).
    • To detail target volumes, dose constraints, and simulation/planning/delivery techniques for NSCLC RT.

    Main Methods:

    • Review of NCCN Clinical Practice Guidelines for NSCLC.
    • Focus on general principles, target volumes, dose constraints, and RT delivery for early-stage, locally advanced, and advanced/metastatic NSCLC.

    Main Results:

    • Established RT principles for early-stage, locally advanced, and advanced/metastatic NSCLC.
    • Defined target volumes, prescription doses, and normal tissue dose constraints.
    • Outlined RT simulation, planning, and delivery protocols.

    Conclusions:

    • Radiation therapy is a key modality in NSCLC management across all disease stages.
    • Adherence to established guidelines and multidisciplinary team collaboration ensures optimal RT delivery for NSCLC patients.