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The unexpected evolution of basic science studies about cyclic nucleotide action into a treatment for erectile

Jackie Corbin1

  • 1From the Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, Tennessee 37232 jackie.corbin@vanderbilt.edu.

The Journal of Biological Chemistry
|December 16, 2014
PubMed
Summary

Basic science research into cyclic nucleotides led to the development of phosphodiesterase type 5 (PDE5) inhibitors. These discoveries now treat erectile dysfunction, improving patient health outcomes.

Keywords:
Cyclic AMP (cAMP)Cyclic GMP (cGMP)PhosphodiesterasesProtein Kinase A (PKA)Protein Kinase G (PKG)

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