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Natriuretic hormones in brain function
Anastasia Hodes1, David Lichtstein1
1Faculty of Medicine, Department of Medical Neurobiology, Institute for Medical Research Israel-Canada, The Hebrew University of Jerusalem , Jerusalem , Israel.
Frontiers in Endocrinology
|December 16, 2014
Summary
Natriuretic hormones (NH) regulate body fluid balance and blood pressure. This review highlights their crucial roles in brain function, including neuroprotection and psychiatric conditions.
Area of Science:
- Endocrinology
- Neuroscience
- Physiology
Background:
- Natriuretic hormones (NH) comprise natriuretic peptides, gastrointestinal peptides, and cardiac steroids.
- These hormones are key regulators of sodium-homeostasis, blood volume, and blood pressure.
- Beyond peripheral roles, NH function as neurotransmitters/neuromodulators in the central nervous system.
Purpose of the Study:
- To review the biosynthesis, release, and function of NH.
- To focus on the specific roles of NH within the brain.
- To summarize current knowledge on NH and their receptors in the brain.
Main Methods:
- Literature review of established information on NH.
- Summary of expression patterns of NH and their receptors in the brain.
- Evidence-based analysis of NH's modulatory roles in brain function.
Main Results:
- NH are expressed in various brain regions and influence central blood pressure regulation.
- Evidence suggests NH involvement in neuroprotection, satiety, and psychiatric disorders (anxiety, addiction, depression).
- Interactions between peripheral and central NH are significant.
Conclusions:
- NH play a vital role in the central regulation of physiological and behavioral processes.
- Further research is needed to fully elucidate the complex functions of NH in the brain.
- NH represent a promising area for understanding and potentially treating neurological and psychiatric conditions.
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