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Propane-d6 Heterogeneously Hyperpolarized by Parahydrogen
Kirill V Kovtunov1, Milton L Truong2, Danila A Barskiy1
1International Tomography Center , 3A Institutskaya St., Novosibirsk 630090, Russia ; Novosibirsk State University , 2 Pirogova St., Novosibirsk, 630090, Russia.
The Journal of Physical Chemistry. C, Nanomaterials and Interfaces
|December 16, 2014
Summary
Hyperpolarized propane-d6 gas, created using parahydrogen and a solid catalyst, shows long spin state lifetimes. This breakthrough enables direct detection at low magnetic fields, paving the way for advanced bioimaging applications.
Area of Science:
- Nuclear Magnetic Resonance (NMR) Spectroscopy
- Medical Imaging
- Catalysis
Background:
- Hyperpolarized gases offer enhanced sensitivity for Magnetic Resonance Imaging (MRI).
- Parahydrogen-induced polarization (PHIP) is a key technique for generating hyperpolarized molecules.
- Heterogeneous catalysis provides a platform for efficient synthesis of hyperpolarized compounds.
Purpose of the Study:
- To demonstrate long-lived spin states of hyperpolarized propane-d6 gas.
- To explore the feasibility of detecting hyperpolarized propane-d6 at low magnetic fields.
- To assess the potential of this method for bioimaging applications.
Main Methods:
- Synthesis of hyperpolarized propane-d6 using heterogeneous parahydrogen-induced polarization (HET-PHIP) with a Rh/TiO2 solid catalyst.
- Detection of hyperpolarized propane-d6 at high magnetic fields (9.4 T) using spectroscopy and 3D MRI.
- Low-field detection (0.0475 T) using stopped-flow and 2D MRI, assessing spin polarization and lifetime.
- Evaluation of susceptibility to paramagnetic impurities (oxygen).
Main Results:
- Achieved hyperpolarized propane-d6 with nuclear spin polarization (P_H) of ~1% at high field and ~0.1% at low field.
- Demonstrated long effective spin-lattice relaxation times (T1,eff) of 6.0 ± 0.3 s at low field.
- Confirmed direct detection of hyperpolarized protons at low magnetic field.
- Showed robustness against paramagnetic impurities, withstanding ~0.2 atm oxygen exposure.
- Achieved high-resolution low-field 2D MRI with 0.88 × 0.88 mm² spatial resolution and ~0.7 s temporal resolution.
Conclusions:
- Long-lived spin states of hyperpolarized propane-d6 can be achieved using HET-PHIP.
- Direct, high-resolution detection at low magnetic fields is feasible, offering advantages for bioimaging.
- The stability and nontoxic nature of propane gas make it a promising candidate for pulmonary low-field MRI.
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