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Related Experiment Video

Updated: Apr 19, 2026

Generation of Fluorescent Protein Fusions in Candida Species

Generation of Fluorescent Protein Fusions in Candida Species

Published on: March 4, 2017

Congenital candidiasis.

Chintaginjala Aruna¹, Kolalapudi Seetharam¹

¹Department of Dermatology, Venereology and Leprosy, Katuri Medical College, Guntur, Andhra Pradesh, India.

Indian Dermatology Online Journal

|December 16, 2014

Summary

This summary is machine-generated.

Congenital candidiasis (CC) is a rare newborn skin condition. Early diagnosis and treatment of invasive Candida albicans infections are crucial to prevent severe complications and mortality.

Keywords:

Candidiasis congenital fluconazole pustular eruption

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Area of Science:

Neonatology
Infectious Diseases
Dermatology

Background:

Congenital candidiasis (CC) is a rare fungal infection in newborns, with fewer than 100 reported cases.
It manifests within the first six days of life, ranging from skin lesions to life-threatening systemic illness.
Prompt differentiation from other neonatal pustular conditions is vital to prevent complications.

Observation:

A neonate presented with a diffuse pustular eruption on an erythematous background affecting the face, trunk, and palms within 24 hours of birth.
Candida albicans was identified via potassium hydroxide (KOH) smear and culture from the pustular lesions.
The infant received intravenous fluconazole and topical ketoconazole for treatment.

Findings:

The neonate demonstrated a complete clinical improvement within two weeks of initiating antifungal therapy.
Diagnosis was confirmed by laboratory identification of Candida albicans in skin lesions.
Intravenous and topical antifungal treatment led to resolution of the congenital candidiasis.

Implications:

This case highlights the importance of recognizing congenital candidiasis in neonates presenting with pustular rashes.
Early and accurate diagnosis is critical for effective management and improved patient outcomes.
Timely treatment of CC can significantly reduce the high mortality rate associated with untreated invasive fungal infections in newborns.