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Updated: Apr 19, 2026
Control of Cell Adhesion using Hydrogel Patterning Techniques for Applications in Traction Force Microscopy
Published on: January 29, 2022
Conformal nanopatterning of extracellular matrix proteins onto topographically complex surfaces
Yan Sun1, Quentin Jallerat2, John M Szymanski2
11] Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, Pennsylvania, USA. [2] School of Biological Science and Medical Engineering, Beihang University, Beijing, China.
Abstract:
Our Patterning on Topography (PoT) printing technique enables fibronectin, laminin and other proteins to be applied to biomaterial surfaces in complex geometries that are inaccessible using traditional soft lithography techniques. Engineering combinatorial surfaces that integrate topographical and biochemical micropatterns enhances control of the biotic-abiotic interface. Here, we used this method to understand cardiomyocyte response to competing physical and chemical cues in the microenvironment.
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