Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Appendicitis01:19

Appendicitis

17
Appendicitis is an acute inflammatory condition of the vermiform appendix, most commonly caused by obstruction of its lumen. The appendix is a narrow, blind-ended pouch that extends from the cecum, making it particularly prone to obstruction. Causes include fecaliths, lymphoid hyperplasia (often after viral infections), parasites, tumors, or foreign bodies. This obstruction initiates a cascade of pathological changes.Luminal Obstruction and Early InflammationAfter obstruction, normal mucosal...
17
Appendicitis-I: Introduction01:22

Appendicitis-I: Introduction

4.1K
The appendix, a small, narrow, blind tube extending from the inferior part of the cecum, is widely regarded as a vestigial organ, having lost much of its original function through evolution. Despite its diminished role, the appendix can become inflamed, a condition known as appendicitis.
Etiology: Appendicitis can arise from various causes, primarily rooted in the obstruction of the appendix lumen. Factors contributing to this obstruction include fecal accumulation, lymphoid hyperplasia and, in...
4.1K
Appendicitis-II: Diagnostic Studies and Management01:29

Appendicitis-II: Diagnostic Studies and Management

903
Diagnosing and managing appendicitis requires a structured and comprehensive approach that spans from initial assessment to postoperative care. Here is an overview of the process:
Diagnosing Appendicitis
It requires a multifaceted approach, starting with a detailed physical examination to pinpoint the location and nature of the pain and identify any associated symptoms. Laboratory tests play a crucial role. A complete Blood Count (CBC) typically reveals leukocytosis (an increased number of...
903
Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

10.6K
Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
10.6K
Cholecystitis01:20

Cholecystitis

20
Cholecystitis is inflammation of the gallbladder, most commonly caused by obstruction of the cystic duct. This blockage prevents bile from draining, leading to gallbladder distension, inflammation, and potentially serious complications. This condition may present acutely or chronically and can happen with or without gallstones.EtiologyAbout 95% of cholecystitis cases are calculous, caused by gallstones blocking the cystic duct, leading to bile accumulation and inflammation of the gallbladder...
20
Acute Pancreatitis I: Introduction01:25

Acute Pancreatitis I: Introduction

16
Acute pancreatitis is the sudden inflammation of the pancreas caused by the early activation of digestive enzymes, leading to the autodigestion of pancreatic tissue. This results in local inflammation and, in severe cases, systemic complications.EtiologyUnderstanding the underlying causes is crucial, as identifying the etiology guides treatment and anticipates complications. Acute pancreatitis can be triggered by various factors, typically grouped into the following clinical categories.Biliary...
16

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mapping the Common Carotid Artery Bifurcation Utilizing Anterior Neck Landmarks.

Diagnostics (Basel, Switzerland)·2026
Same author

Correction: Deep brain stimulation for Parkinson's disease in India: an expert consensus on availability, affordability, and eligibility by the Parkinson's research alliance India (PRAI).

Journal of neural transmission (Vienna, Austria : 1996)·2026
Same author

The Efficacy and Safety of N-acetylcysteine and Taurine (Nefrosave®) in Chronic Kidney Disease: A Double-Blind, Multicenter, Placebo-Controlled Trial (DELAY-CKD).

Cureus·2026
Same author

Severe Hyponatremia Presenting With Mild Symptoms and Multifactorial Etiology.

Journal of community hospital internal medicine perspectives·2026
Same author

Superior Segmental Optic Nerve Hypoplasia: A Case Report and Literature Review.

Cureus·2026
Same author

Deep brain stimulation for Parkinson's disease in India: an expert consensus on availability, affordability, and eligibility by the Parkinson's research alliance India (PRAI).

Journal of neural transmission (Vienna, Austria : 1996)·2026

Related Experiment Video

Updated: Apr 19, 2026

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
10:52

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

11.8K

Mantle cell lymphoma presenting as acute appendicitis.

Max Chae1, Sampath Kumar1, Muhammad Cheema2

  • 1Surgery Department, Lutheran Medical Center, 150 55th Street, Brooklyn 11220, NY, USA.

International Journal of Surgery Case Reports
|December 16, 2014
PubMed
Summary

Mantle cell lymphoma, a rare cancer, can cause acute appendicitis by obstructing the appendix. This case highlights lymphoma directly causing appendicitis before chemotherapy treatment.

Keywords:
AppendicitisChemotherapyMantle cell lymphomaObstruction of appendiceal lumen

More Related Videos

Bioprinting of Hydrogel Tumor Slices as a 3D Model for Mantle Cell Lymphoma
08:31

Bioprinting of Hydrogel Tumor Slices as a 3D Model for Mantle Cell Lymphoma

Published on: September 12, 2025

1.0K
Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch
08:51

Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch

Published on: August 24, 2019

10.9K

Related Experiment Videos

Last Updated: Apr 19, 2026

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
10:52

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

11.8K
Bioprinting of Hydrogel Tumor Slices as a 3D Model for Mantle Cell Lymphoma
08:31

Bioprinting of Hydrogel Tumor Slices as a 3D Model for Mantle Cell Lymphoma

Published on: September 12, 2025

1.0K
Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch
08:51

Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch

Published on: August 24, 2019

10.9K

Area of Science:

  • Oncology
  • Gastroenterology
  • Pathology

Background:

  • Appendicitis is typically caused by fecaliths or lymphoma obstruction.
  • Mantle cell lymphoma (MCL) is rare, accounting for 4% of U.S. lymphoma cases.
  • Literature primarily reports appendicitis in Burkitt's or large B-cell lymphoma.

Purpose of the Study:

  • To report a rare case of appendicitis caused by mantle cell lymphoma.
  • To describe the clinical presentation and pathological findings of MCL-induced appendicitis.

Main Methods:

  • A 75-year-old male with diagnosed MCL presented with acute appendicitis symptoms.
  • CT scan confirmed appendicitis; laparoscopic appendectomy was performed.
  • Histologic examination revealed MCL occluding the appendiceal lumen.

Main Results:

  • The patient presented with right lower quadrant abdominal pain.
  • Histology confirmed mantle cell lymphoma obstructing the appendix lumen.
  • Appendicitis occurred prior to any chemotherapy treatment.

Conclusions:

  • This is a rare instance of mantle cell lymphoma causing appendiceal lumen obstruction and appendicitis.
  • The obstruction was lymphoma-driven, independent of chemotherapy.
  • Highlights a distinct mechanism of lymphoma-associated appendicitis.