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[Occurrences of human papilloma virus DNA in cervical carcinomas]
H Ichimura1, M Yamasaki, I Tamura
1Institute of Clinical Research, Kure National Hospital.
Gan No Rinsho. Japan Journal of Cancer Clinics
|September 1, 1989
Abstract:
Out of 16 cases involving a cervical carcinoma that were investigated by Southern blot hybridization, found were human papilloma virus (HPV) types 16 and 18 DNA sequences in 8 (50%) and in one (6.3%), respectively. Six out of the 8 HPV 16-positive specimens were from squamous cell carcinomas, one was from an adenocarcinoma, and the remaining specimen was from an argyrophil small cell carcinoma. In 7 out of 9 HPV-positive specimens, the viral sequences were integrated in the tumor cell genome, whereas in the remaining two they were not integrated and remained circular and/or oligomeric in form.