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Updated: Apr 19, 2026
Co-culture of Glioblastoma Stem-like Cells on Patterned Neurons to Study Migration and Cellular Interactions
Published on: February 24, 2021
Glioblastoma multiforme formation and EMT: role of FoxM1 transcription factor
Zhongyong Wang, Sicong Zhang, Timothy L Siu
1Department of Neurosurgery, the University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. suhuang@mdanderson.org.
Abstract:
Glioblastoma multiforme (GBM) is one of the most malignant cancers in human brain. The prognosis of GBM is extremely poor because it is resistant to radiotherapy and chemotherapy. Improving understanding of the tumor biology brings some new hope to the treatment of GBM. In this review, we discuss the evidence that FoxM1 promotes the development and progression of GBM by regulating key factors involved in cell proliferation, epithelial to mesenchymal transition (EMT), invasion, angiogenesis and upregulating Wnt/β-catenin signalling. Our recent experimental findings are also summarized to prove that FoxM1 is a novel therapeutic target against GBM.
