[Cytogenetic findings in Wilms' tumor]

We report the cytogenetic analysis of 20 Wilms'tumors. In 10 cases chromosomal abnormalities were found: Besides the expected aberrations involving 11p13 we found chromosome 11 breakpoints at 11p15, 11q13 or q23. Chromosome 1 was frequently involved in rearrangements, with partial trisomy 1q as the typical abnormality. Additional chromosomes 8, 12, 13, 17 and 20 were the most frequent numerical changes. This study is part of efforts to find cytogenetic and molecular markers and constellations contributing important information beyond histology and DNA-measurements.