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Related Experiment Videos

Splanchnic nerve stimulation modulates steroid secretion in hypophysectomized dogs.

W C Engeland1, D S Gann

  • 1Department of Surgery, Rhode Island Hospital/Brown University, Providence.

Neuroendocrinology
|August 1, 1989
PubMed
Summary

Splanchnic nerve stimulation increases cortisol and corticosterone secretion from the adrenal cortex in dogs. This neural input directly influences steroid hormone release, independent of ACTH levels.

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Area of Science:

  • Neuroendocrinology
  • Adrenal Gland Physiology
  • Steroidogenesis

Background:

  • The adrenal cortex produces vital steroid hormones like cortisol.
  • The role of splanchnic neural input in regulating adrenal steroid secretion is not fully understood.

Purpose of the Study:

  • To investigate the effect of thoracic splanchnic nerve stimulation on adrenal cortex steroid secretion in dogs.

Main Methods:

  • Electrically stimulated thoracic splanchnic nerve in hypophysectomized dogs receiving ACTH.
  • Measured adrenal secretion rates of cortisol, corticosterone, 11-deoxycortisol, epinephrine, and norepinephrine.
  • Calculated ACTH presentation rate based on plasma ACTH and adrenal blood flow.

Main Results:

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  • Nerve stimulation increased epinephrine, norepinephrine, and adrenal blood flow in a frequency-dependent manner.
  • Cortisol secretion increased with nerve stimulation at both 4 and 20 Hz, preceding ACTH presentation rate changes.
  • Corticosterone secretion increased at 10 ng/min ACTH infusion, while 11-deoxycortisol secretion decreased.

    • Conclusions:

    • Splanchnic neural input directly stimulates cortisol and corticosterone release from the adrenal cortex.
    • This neural pathway modulates steroidogenesis independently of, or in conjunction with, ACTH levels.