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Updated: Aug 11, 2026

Mechanical Stimulation-induced Calcium Wave Propagation in Cell Monolayers: The Example of Bovine Corneal Endothelial Cells
Published on: July 16, 2013
Modulation of adenylate cyclase activity in bovine lens epithelial cells
Abstract:
Adenylate cyclase activity of bovine lens epithelial cells is activated by guanine nucleotides or fluoride. Additional activation to that of guanylylimidodiphosphate [Gpp(NH)p] was induced by isoproterenol. Insulin was found to inhibit adenylate cyclase activity. Adenosine at low concentrations (5-50 nM) increased adenylate cyclase activity, while at high concentrations it lowered the activity of the enzyme. The occurrence of R and P adenosine sites in lens epithelial cells is suggested. Like other tissues, lens epithelial cells possess a transduction system (adenylate cyclase-G protein complex) for external messages.
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