[Advance in studies on antitumor and immunomodulatory effects of wogonin]

Area of Science:

• Natural product chemistry
• Pharmacology
• Immunology

Background:

• Wogonin is a flavonoid with documented biological activities.
• Emerging research highlights its potential in cancer therapy.

Purpose of the Study:

• To review and summarize the antitumor and immunomodulatory effects of wogonin.
• To consolidate current understanding of wogonin's multi-target mechanisms in cancer.

Main Methods:

• Literature review of preclinical and clinical studies on wogonin.
• Analysis of wogonin's molecular mechanisms against cancer.
• Evaluation of wogonin's impact on immune system components.

Main Results:

• Wogonin demonstrates multi-pathway, multi-target antitumor activities.
• Mechanisms include inducing apoptosis (ROS/Ca2+-mediated), enhancing cytotoxicity (TNF-α, TRAIL), cell cycle arrest, inhibiting angiogenesis, and synergistic effects with chemotherapy.
• Wogonin enhances immune function by promoting immune cell infiltration, regulating phenotypes, and cytokine secretion.

Conclusions:

• Wogonin possesses significant antitumor potential through diverse molecular targets.
• Its immunomodulatory properties further support its role in cancer treatment.
• Further research into wogonin as a therapeutic agent is warranted.