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[Tocolysis with nifedipin; its use in current practice].

V Karamisheva, S Ivanov, D Jordanova

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    Nifedipine effectively manages preterm labor by delaying delivery for antenatal corticosteroid administration, with minimal maternal side effects. This oral tocolytic offers a safe and accessible treatment option for pregnant women.

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    Area of Science:

    • Obstetrics and Gynecology
    • Pharmacology

    Context:

    • Preterm labor management is critical for neonatal outcomes.
    • Tocolytic agents are used to delay birth.
    • Calcium channel blockers, like nifedipine, are increasingly popular due to ease of administration and safety profile.

    Purpose:

    • To evaluate the safety and efficacy of nifedipine as an oral tocolytic agent for preterm labor.
    • To assess the clinical response, gestational age at delivery, and maternal side effects of nifedipine treatment.

    Summary:

    • A prospective study analyzed 88 pregnant women with preterm labor (24-34 weeks gestation) treated with oral nifedipine (40 mg/day).
    • Nifedipine successfully delayed labor by at least 48 hours in 79 pregnancies, allowing for antenatal corticosteroid administration.
    • While common side effects like tachycardia and headache occurred, they were transient and mild.

    Impact:

    • Nifedipine demonstrates efficacy in delaying preterm labor, facilitating crucial antenatal corticosteroid treatment.
    • The study supports nifedipine as a safe and effective oral tocolytic with a favorable maternal side effect profile.
    • Findings contribute to evidence-based guidelines for preterm labor management.