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[Proinflammatory cytokines in patients with pyelonephritis]
Likars'Ka Sprava
|December 17, 2014
Summary
Pro-inflammatory cytokines tumor necrosis factor (TNF), monocyte chemoattractant protein-1 (MCP-1), and interleukin-23 (IL-23) are elevated in both acute and chronic pyelonephritis (PN). MCP-1 may predict acute PN or exacerbations of chronic PN.
Area of Science:
- Immunology
- Pathogenesis of infectious diseases
- Cytokine research
Context:
- Anti-inflammatory cytokines are crucial for anti-infective immunity.
- Understanding cytokine roles in pyelonephritis (PN) pathogenesis is vital.
- Previous research has not fully elucidated cytokine profiles in pediatric and adult PN.
Purpose:
- To quantify pro-inflammatory cytokine levels (TNF, MCP-1, IL-23) in patients with pyelonephritis.
- To differentiate cytokine profiles in acute pyelonephritis (APN) versus chronic pyelonephritis (CPN).
- To compare cytokine levels between pediatric and adult patients with PN.
Summary:
- Elevated levels of TNF, MCP-1, and IL-23 were observed in 173 patients with APN and CPN, including 87 children and 86 adults.
- MCP-1 levels were significantly higher in APN compared to CPN, while TNF and IL-23 did not differ significantly between the two forms.
- Adults generally exhibited higher cytokine levels than children, particularly in APN, suggesting a more pronounced immune response in adults.
Impact:
- The findings confirm the significant role of TNF, MCP-1, and IL-23 in both acute and chronic pyelonephritis.
- MCP-1 emerges as a potential predictive biomarker for acute pyelonephritis or acute exacerbations of chronic pyelonephritis.
- This study highlights age-related differences in immune responses to pyelonephritis, with adults showing a more robust inflammatory profile.
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