[Experemental modeling of ovary hyperstimulation syndrome in test animals]

The experimental simulation of ovary hyperstimulation syndrome (OHSS) in test murine by administration with several dozes of exogenous gonadotropic hormones has been performed. It has been shown that mouse ovary hormone stimulation leads to manifestation of all OHSS symptoms: ovary swelling and hyperemia, injury of their structure, cystic corpus luteum formation, hemorrhagic follicles, folliculogenesis disturbance, oocyte and embryo morphology injury. The degree of OHSS symptom manifestation depends on hormone doze. On the third day after human chorionic gonadotropin administration all OHSS symptoms take place as an evidence of this syndrome prolonged character.