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Related Experiment Video

Updated: Apr 19, 2026

Author Spotlight: Analyzing Bone Marrow Microenvironment in Murine Hematological Malignancies

Author Spotlight: Analyzing Bone Marrow Microenvironment in Murine Hematological Malignancies

Published on: November 10, 2023

Targeting the bone marrow microenvironment in multiple myeloma.

Yawara Kawano¹, Michele Moschetta, Salomon Manier

¹Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.

Immunological Reviews

|December 17, 2014

Summary

Multiple myeloma (MM) is a fatal blood cancer. The bone marrow microenvironment supports cancer cell survival and drug resistance, necessitating new therapeutic strategies targeting this interaction.

Keywords:

BMSCs bone marrow immune cells myeloma vessel formation

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Bioengineering of Humanized Bone Marrow Microenvironments in Mouse and Their Visualization by Live Imaging

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Published on: August 1, 2017

Area of Science:

Hematology
Oncology
Cancer Biology

Background:

Multiple myeloma (MM) involves malignant plasma cell proliferation in the bone marrow (BM).
Despite treatment advances, MM remains a fatal malignancy.
The BM microenvironment is crucial for MM cell survival, proliferation, migration, and drug resistance.

Purpose of the Study:

To review the complex interactions between malignant plasma cells and the BM microenvironment.
To discuss therapeutic strategies targeting the BM microenvironment in MM.

Main Methods:

Literature review of studies on MM pathogenesis and BM microenvironment.
Analysis of cellular and non-cellular components of the BM microenvironment.
Synthesis of current and emerging therapeutic strategies.

Main Results:

The BM microenvironment provides essential support for MM progression.
Specific cellular and non-cellular components facilitate MM cell survival and resistance.
Targeting the BM microenvironment offers potential for novel MM therapies.

Conclusions:

Understanding MM-BM microenvironment interactions is key to overcoming treatment resistance.
Targeting the BM microenvironment represents a promising therapeutic avenue for multiple myeloma.