Related Experiment Video
Updated: Aug 19, 2026

High-throughput Screening for Small-molecule Modulators of Inward Rectifier Potassium Channels
Published on: January 27, 2013
[The Na+/H+ antiport: a target for new antihypertensive agents]
Abstract:
The sodium-hydrogen (Na+/H+) antiport is electroneutral and amiloride-sensitive. It exchanges Na+ for H+ with a coupling ratio of 1:1 and therefore, it has important cellular functions: intracellular pH and cell volume regulation, control of the cell differentiation and growth. Its activity is increased in hypertension. The responsibility of the Na+/H+ antiport in essential hypertension may result in increased vascular tone and vascular hyperplasia. Amiloride is a specific inhibitor of this exchanger but under physiological conditions, very high concentrations of this drug (that are unlikely to be attained in vivo) are required to inhibit the activity of the Na+/H+ antiport. Certain of its analogues are much more potent in vitro than amiloride. Therefore, the Na+/H+ antiport may become a target for new antihypertensive drugs.
More Related Videos
07:38Functional Characterization of Na+/H+ Exchangers of Intracellular Compartments Using Proton-killing Selection to Express Them at the Plasma Membrane
Published on: March 30, 2015
09:12Selection of Transporter-Targeted Inhibitory Nanobodies by Solid-Supported-Membrane (SSM)-Based Electrophysiology
Published on: May 3, 2021
Related Concept Videos
Antihypertensive Drugs: Action of Diuretics
Antihypertensive Drugs: Action of Calcium Channel Blockers
Antihypertensive Drugs: Angiotensin II Receptor Blockers
Antihypertensive Drugs: Vasodilators
Antiarrhythmic Drugs: Class I Agents as Sodium Channel Blockers
Class 1A Antiarrhythmic Drugs: These drugs work by moderately blocking sodium channels,...
Active Transport
Primary active transporters, like Na+, K+ and -ATPase, directly utilize ATP to move ions across the membrane. These transporters play significant roles in various physiological processes. For instance, Na+, K+ and -ATPase maintain...