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Isolation and characterization of Mayaro virus from a human in Acre, Brazil

Ana Carolina B Terzian1, Albert J Auguste1, Danila Vedovello1

  • 1Faculdade de Medicina de São José do Rio Preto, São José do Rio Preto, SP, Brazil; Institute for Human Infections and Immunity, Center for Tropical Diseases and Department of Pathology, University of Texas Medical Branch, Galveston, Texas; Instituto de Ciências Biológicas/Universidade de São Paulo, São Paulo, Brazil; Universidade Federal do ABC, Santo André, São Paulo, Brazil; Universidade Estadual Paulista, Botucatu, São Paulo, Brazil.

The American Journal of Tropical Medicine and Hygiene
|December 17, 2014
PubMed

Insights

Mayaro virus (MAYV) causes fever, but this study sequenced a strain from Brazil. This Mayaro virus isolate belongs to genotype D and is closely related to South American strains.

Area of Science:

  • Virology
  • Epidemiology
  • Genomics

Background:

  • Mayaro virus (MAYV) causes Mayaro fever, an acute febrile illness prevalent in South America.
  • MAYV symptoms overlap with other tropical diseases, leading to underdiagnosis.
  • Arthralgia is a common Mayaro fever symptom, but not always present.

Purpose of the Study:

  • To sequence the complete genome of a Mayaro virus isolate from Brazil.
  • To determine the genetic lineage and evolutionary relationship of this isolate.

Main Methods:

  • Whole genome sequencing of the Mayaro virus isolate.
  • Phylogenetic analysis to determine genotype and relationship to other strains.

Main Results:

  • The complete genome sequence of a novel Mayaro virus isolate was obtained.
  • Phylogenetic analysis confirmed the isolate belongs to genotype D.
  • The Acre/Mayaro strain is closely related to Bolivian Mayaro virus strains from 2002-2006.

Conclusions:

  • The study provides the full genome sequence of a Mayaro virus genotype D strain.
  • This isolate offers insights into the evolutionary history of Mayaro virus in South America.
  • The findings contribute to understanding Mayaro virus diversity and epidemiology.

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