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Published on: December 11, 2016
Increased interventricular septum wall thickness predicts all-cause death in patients with coronary artery disease
1Department of Cardiology, West China Hospital, Sichuan University, Chengdu, China.
Insights
Interventricular septum (IVS) thickness predicts death in Chinese coronary artery disease (CAD) patients. Even mild thickening increases mortality risk, highlighting IVS as a reliable prognostic marker.
Area of Science:
- Cardiology
- Clinical Medicine
- Medical Diagnostics
Background:
- The prognostic significance of interventricular septum (IVS) wall thickness is debated.
- Assessing IVS thickness may offer predictive value for adverse cardiovascular events.
Purpose of the Study:
- To investigate the association between interventricular septum (IVS) wall thickness severity and all-cause mortality.
- To evaluate the predictive value of IVS thickness in Chinese patients with coronary artery disease (CAD).
Main Methods:
- A cohort of 2297 coronary artery disease (CAD) patients, confirmed by angiography, was analyzed.
- Patients were stratified based on interventricular septum (IVS) wall thickness severity.
- Cox regression analysis was employed to determine the independent prognostic value of IVS thickness for all-cause death.
Main Results:
- A median follow-up of 25 months revealed 149 deaths.
- A significant gradient increase in mortality risk was observed with increasing interventricular septum (IVS) thickness.
- Mildly thickened IVS showed a 1.49-fold increased risk (HR 1.49, P=0.05), while moderately/severely thickened IVS showed a 2.13-fold increased risk (HR 2.13, P=0.003) for all-cause death compared to normal IVS thickness.
Conclusions:
- Elevated interventricular septum (IVS) wall thickness is a reliable predictor of all-cause mortality in Chinese patients with coronary artery disease (CAD).
- This predictive value persists even in patients with normal indexed left ventricular mass.
- IVS thickness serves as a valuable prognostic marker in CAD management.
Background:
There is debate regarding the predictive value of interventricular septum (IVS) wall thickness for adverse events.
Aims:
The study investigated the association between the severity of thickened IVS and all-cause death in Chinese patients with coronary artery disease (CAD).
Methods:
A total of 2297 CAD patients verified by angiography was consecutively included. Patients were grouped according to the severity of thickened IVS. Cox regression analysis was conducted to determine the independent prognostic value of thickened IVS for all-cause death.
Results:
During a median follow up of 25 months, 149 patients died. A gradient increase in the risk of death was observed across thickened IVS groups. Compared to patients with normal IVS thickness, the adjusted hazard ratio (HR) was 1.49 (95% confidence interval (CI) 1.00-2.23, P = 0.05) and 2.13 (95% CI 1.29-3.54, P = 0.003) for all-cause death in those with mildly and moderately/severely thickened IVS respectively. For one unit increase in IVS thickness, the risk of all-cause death was elevated by 14% (adjusted HR 1.14, 95% CI 1.05-1.24, P = 0.003). In patients with normal indexed left ventricular mass, thickened IVS was also demonstrated as an independent risk factor for all-cause death.
Conclusion:
Thickened IVS can be served as a reliable marker for predicting all-cause death in Chinese patients with CAD, even in those with normal left ventricular mass.
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