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Published on: November 11, 2021
Pediatric meningiomas an aggressive subset: a clinicopathological and immunohistochemical study
M Hui, M S Uppin, M Vijaya Saradhi
1Department of Pathology, Nizam's Institute of Medical Sciences, Hyderabad, Andhra Pradesh, India.
Background:
Meningiomas are uncommon neoplasms in the pediatric age group and differ in various aspects from their adult counterparts. They account for 0.4-4.6% of all primary brain tumors.
Aims:
To retrospectively analyze the clinicopathological and immunohistochemical features of pediatric meningiomas.
Materials And Methods:
Meningiomas in patients under 18 years of age diagnosed between January 2001 to December 2011 were analyzed retrospectively. The hematoxylin and eosin stained sections and Ki 67 labelling index (LI) were reviewed for all the cases Results: The pediatric meningiomas accounted for 1.52% of total meningiomas (15/983). The mean age at presentation was 12 years with male to female ratio of 1.5:1. The presenting symptoms were headache, seizures, and motor deficits. The histology included 9 cases (60%) of atypical meningioma (WHO grade II) followed by 4 cases (26.67%) of WHO grade-I and 2 cases (13.33%) of anaplastic meningioma (WHO grade III). Five cases had a recurrence. Ki67 LI ranged from 0.5% to 1.5% in grade I, 0.5% to 15% in grade II and 13% to 24% in grade III meningiomas.
Conclusion:
Meningiomas are rare in children and show a male preponderance. There was a higher incidence of atypical and anaplastic meningiomas in pediatric population.
Insights
Pediatric meningiomas are rare brain tumors with a male predominance. This study found a higher incidence of aggressive atypical and anaplastic meningiomas in children compared to adults.
Area of Science:
- Pediatric neuro-oncology
- Tumor pathology
- Cancer research
Background:
- Meningiomas are rare in children, representing a small fraction of primary brain tumors.
- Pediatric meningiomas exhibit distinct characteristics compared to adult counterparts.
Purpose of the Study:
- To retrospectively analyze the clinicopathological and immunohistochemical features of pediatric meningiomas.
- To understand the unique aspects of meningiomas in patients under 18 years of age.
Main Methods:
- Retrospective analysis of pediatric meningiomas diagnosed between 2001 and 2011.
- Review of hematoxylin and eosin stained sections and Ki 67 labeling index (LI).
Main Results:
- Pediatric meningiomas constituted 1.52% of all meningiomas.
- The mean age was 12 years, with a male-to-female ratio of 1.5:1.
- Histology revealed a higher proportion of atypical (WHO grade II) and anaplastic (WHO grade III) meningiomas.
Conclusions:
- Meningiomas are rare in children and show a male preponderance.
- Pediatric meningiomas have a higher incidence of aggressive subtypes (WHO grade II and III).
