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Neutrophils in asthma--a review
Olga Ciepiela1, Magdalena Ostafin1, Urszula Demkow1
1Department of Laboratory Diagnostics and Clinical Immunology of Developmental Age, Medical University of Warsaw, Marszałkowska 24, 00-576 Warsaw, Poland.
Respiratory Physiology & Neurobiology
|December 17, 2014
Summary
Neutrophils play a complex role in asthma, a chronic inflammatory airway disease. These immune cells can activate other cells and contribute to airway remodeling, impacting asthma development.
Area of Science:
- Immunology
- Pulmonology
- Cell Biology
Background:
- Asthma is a chronic inflammatory airway disease involving multiple cell types.
- Neutrophils are implicated in asthma pathogenesis, but their precise role is complex.
- Understanding cellular contributions is key to managing asthma.
Purpose of the Study:
- To review and highlight the specific role of neutrophils in bronchial asthma.
- To elucidate the mechanisms by which neutrophils influence asthma development.
- To consolidate current knowledge on neutrophil involvement in airway inflammation and remodeling.
Main Methods:
- Literature review of studies on neutrophils and asthma.
- Analysis of research focusing on cellular interactions in asthma pathogenesis.
- Synthesis of findings regarding neutrophil-derived mediators and their effects.
Main Results:
- Neutrophils are involved in activating immunocompetent cells.
- They are a significant source of free oxygen radicals.
- Neutrophils release enzymes that contribute to airway remodeling in asthma.
Conclusions:
- Neutrophils have a multifaceted role in the development and progression of bronchial asthma.
- Their involvement extends to triggering immune responses and structural airway changes.
- Further research into neutrophil function is crucial for asthma management strategies.
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