Investigating the anti-leishmanial effects of linear peptoids
Gabriela A Eggimann1, Hannah L Bolt, Paul W Denny
1Biophysical Sciences Institute, Department of Chemistry, Durham University, South Road, Durham, DH1 3LE (UK).
Chemmedchem
|December 17, 2014
Abstract:
Peptoids, a class of peptide mimetics, have emerged as promising anti-infective agents against a range of bacterial infections. Herein we present the first study of the antiparasitic and specifically the anti-leishmanial properties of linear peptoids. Peptoids were identified as having promising activity against Leishmania mexicana axenic amastigotes, a causative agent of cutaneous leishmaniasis.


